Multi-institutional retrospective review of stereotactic radiosurgery for brain metastasis in patients with small cell lung cancer without prior brain-directed radiotherapy

Patients with small cell lung cancer (SCLC) brain metastasis (BM) typically receive whole brain radiotherapy (WBRT) as data regarding upfront radiosurgery (SRS) in this setting are sparse. Patients receiving SRS for SCLC BM without prior brain radiation were identified at three U.S. institutions. Ov...

Full description

Saved in:
Bibliographic Details
Published in:Journal of radiosurgery and SBRT 2020, Vol.7 (1), p.19-27
Main Authors: Miccio, Joseph A, Barsky, Andrew, Gao, Sarah, Verma, Vivek, Noticewala, Sonal S, Jairam, Vikram, Johnson, Skyler B, Yu, James B, Hansen, James E, Aneja, Sanjay, An, Yi, Decker, Roy H, Bulent Omay, S, Li, Jing, Kurtz, Goldie A, Alonso-Basanta, Michelle, Lee, John Y K, Chiang, Veronica L, Park, Henry S
Format: Article
Language:English
Subjects:
Clinical Investigation
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Patients with small cell lung cancer (SCLC) brain metastasis (BM) typically receive whole brain radiotherapy (WBRT) as data regarding upfront radiosurgery (SRS) in this setting are sparse. Patients receiving SRS for SCLC BM without prior brain radiation were identified at three U.S. institutions. Overall survival (OS), freedom from intracranial progression (FFIP), freedom from WBRT (FFWBRT), and freedom from neurologic death (FFND) were determined from time of SRS. Thirty-three patients were included with a median of 2 BM (IQR 1-6). Median OS and FFIP were 6.7 and 5.8 months, respectively. Median FFIP for patients with ≤2 versus >2 BM was 7.1 versus 3.6 months, p=0.0303. Eight patients received salvage WBRT and the 6-month FFWBRT and FFND were 87.8%. and 90.1%, respectively. Most SCLC patients with BM who received upfront SRS avoided WBRT and neurologic death, suggesting that SRS may be an option in select patients.
ISSN:2156-4639
2156-4647