Indirect cell death and the LQ model in SBRT and SRS

High-dose hypofractionated SBRT and SRS indirectly kills substantial fractions of tumor cells via causing vascular damage. The LQ formula may work well for certain clinical cases of SBRT and SRS when the indirect/additional tumor cell death secondary to vascular damage is small. However, when the in...

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Bibliographic Details
Published in:Journal of radiosurgery and SBRT 2020, Vol.7 (1), p.1-4
Main Authors: Song, Chang W, Terezakis, Stephanie, Emami, Bahman, Griffin, Robert J, Sperduto, Paul W, Kim, Mi-Sook, Cho, L Chinsoo
Format: Article
Language:English
Subjects:
Review
Online Access:Get full text
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Summary:High-dose hypofractionated SBRT and SRS indirectly kills substantial fractions of tumor cells via causing vascular damage. The LQ formula may work well for certain clinical cases of SBRT and SRS when the indirect/additional tumor cell death secondary to vascular damage is small. However, when the indirect cell death is extensive, the LQ model will underestimate the clinical outcome of SBRT and SRS.
ISSN:2156-4639
2156-4647