Components of the Lectin Pathway of Complement in Haematologic Malignancies

The complement system is activated cascadically via three distinct major routes: classical pathway (CP), alternative pathway (AP) or lectin pathway (LP). The unique factors associated with the latter are collectins (mannose-binding lectin, collectin-10, collectin-11), ficolins (ficolin-1, ficolin-2,...

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Bibliographic Details
Published in:Cancers 2020-07, Vol.12 (7), p.1792
Main Authors: Cedzyński, Maciej, Świerzko, Anna S
Format: Article
Language:English
Subjects:
Alternative pathway
Bone marrow
Cancer
Carbohydrates
Chemotherapy
Chronic illnesses
Classical pathway
Collagen
Collectins
Complement activation
Ficolins
Gram-positive bacteria
Haplotypes
Hematology
Lectins
Leukemia
Ligands
Lymphoma
Mannose
Mannose-binding lectin
Mannose-binding protein-associated serine proteinase
MASP-1 protein
MASP-2 protein
Mutation
Pathogens
Proteins
Proteolysis
Proteolytic enzymes
Review
Serine
Serine proteinase
Stem cells
Tumors
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Summary:The complement system is activated cascadically via three distinct major routes: classical pathway (CP), alternative pathway (AP) or lectin pathway (LP). The unique factors associated with the latter are collectins (mannose-binding lectin, collectin-10, collectin-11), ficolins (ficolin-1, ficolin-2, ficolin-3) and proteins of the mannose-binding lectin-associated serine protease (MASP) family (MASP-1, MASP-2, MASP-3, MAp19, MAp44). Collectins and ficolins are both pattern-recognising molecules (PRM), reactive against pathogen-associated molecular patterns (PAMP) or danger-associated molecular patterns (DAMP). The MASP family proteins were first discovered as complexes with mannose-binding lectin (MBL) and therefore named MBL-associated serine proteases, but later, they were found to interact with ficolins, and later still, collectin-10 and collectin-11. As well as proteolytic enzymes (MASP-1, MASP-2, MASP-3), the group includes non-enzymatic factors (MAp19, MAp44). In this review, the association-specific factors of the lectin pathway with haematologic malignancies and related infections are discussed.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers12071792