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Enhanced Salivary and General Oxidative Stress in Hashimoto’s Thyroiditis Women in Euthyreosis
Hashimoto’s thyroiditis (HT) is one of the most common autoimmune diseases. Although HT is inextricably linked to oxidative stress, there have been no studies assessing salivary redox homeostasis or salivary gland function in patients with HT. This study is the first to compare antioxidant defense a...
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Published in: | Journal of clinical medicine 2020-07, Vol.9 (7), p.2102 |
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description | Hashimoto’s thyroiditis (HT) is one of the most common autoimmune diseases. Although HT is inextricably linked to oxidative stress, there have been no studies assessing salivary redox homeostasis or salivary gland function in patients with HT. This study is the first to compare antioxidant defense and oxidative stress biomarkers in non-stimulated (NWS) and stimulated (SWS) whole saliva and plasma/erythrocytes of HT patients compared to controls. The study included 45 women with HT in the euthyreosis period as well as an age- and gender-matched control group. We showed that NWS secretion was significantly lower in HT patients compared to healthy controls, similar to salivary amylase activity in NWS and SWS. Catalase and peroxidase activities were considerably higher in NWS and SWS of HT patients, while the concentrations of reduced glutathione and uric acid were significantly lower in comparison with healthy subjects. Total antioxidant potential was significantly lower, while total oxidant status and the level of oxidation products of proteins (advanced glycation end products, advanced oxidation protein products) and lipids (malondialdehyde, lipid hydroperoxides) were significantly higher in NWS, SWS and plasma of HT patients. In conclusion, in both salivary glands of women with HT in euthyreosis, the ability to maintain redox homeostasis was hindered. In HT patients we observed oxidative damage to salivary proteins and lipids; thus, some biomarkers of oxidative stress may present a potential diagnostic value. |
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Although HT is inextricably linked to oxidative stress, there have been no studies assessing salivary redox homeostasis or salivary gland function in patients with HT. This study is the first to compare antioxidant defense and oxidative stress biomarkers in non-stimulated (NWS) and stimulated (SWS) whole saliva and plasma/erythrocytes of HT patients compared to controls. The study included 45 women with HT in the euthyreosis period as well as an age- and gender-matched control group. We showed that NWS secretion was significantly lower in HT patients compared to healthy controls, similar to salivary amylase activity in NWS and SWS. Catalase and peroxidase activities were considerably higher in NWS and SWS of HT patients, while the concentrations of reduced glutathione and uric acid were significantly lower in comparison with healthy subjects. Total antioxidant potential was significantly lower, while total oxidant status and the level of oxidation products of proteins (advanced glycation end products, advanced oxidation protein products) and lipids (malondialdehyde, lipid hydroperoxides) were significantly higher in NWS, SWS and plasma of HT patients. In conclusion, in both salivary glands of women with HT in euthyreosis, the ability to maintain redox homeostasis was hindered. In HT patients we observed oxidative damage to salivary proteins and lipids; thus, some biomarkers of oxidative stress may present a potential diagnostic value.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm9072102</identifier><identifier>PMID: 32635382</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Antioxidants ; Autoimmune diseases ; Clinical medicine ; Diabetes ; Disease ; Exocrine glands ; Hormones ; Lupus ; Oxidation ; Oxidative stress ; Patients ; Plasma ; Psoriasis ; Rheumatoid arthritis ; Thyroid gland ; Womens health</subject><ispartof>Journal of clinical medicine, 2020-07, Vol.9 (7), p.2102</ispartof><rights>2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c313t-1220508f3041b7a1692798f479470619a8f67811be65a1ec2e2bdbdee3938cae3</citedby><cites>FETCH-LOGICAL-c313t-1220508f3041b7a1692798f479470619a8f67811be65a1ec2e2bdbdee3938cae3</cites><orcidid>0000-0001-5609-3187 ; 0000-0003-4562-0951 ; 0000-0002-4522-4978</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2641150028/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2641150028?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25732,27903,27904,36991,36992,44569,53769,53771,74872</link.rule.ids></links><search><creatorcontrib>Morawska, Katarzyna</creatorcontrib><creatorcontrib>Maciejczyk, Mateusz</creatorcontrib><creatorcontrib>Popławski, Łukasz</creatorcontrib><creatorcontrib>Popławska-Kita, Anna</creatorcontrib><creatorcontrib>Krętowski, Adam</creatorcontrib><creatorcontrib>Zalewska, Anna</creatorcontrib><title>Enhanced Salivary and General Oxidative Stress in Hashimoto’s Thyroiditis Women in Euthyreosis</title><title>Journal of clinical medicine</title><description>Hashimoto’s thyroiditis (HT) is one of the most common autoimmune diseases. Although HT is inextricably linked to oxidative stress, there have been no studies assessing salivary redox homeostasis or salivary gland function in patients with HT. This study is the first to compare antioxidant defense and oxidative stress biomarkers in non-stimulated (NWS) and stimulated (SWS) whole saliva and plasma/erythrocytes of HT patients compared to controls. The study included 45 women with HT in the euthyreosis period as well as an age- and gender-matched control group. We showed that NWS secretion was significantly lower in HT patients compared to healthy controls, similar to salivary amylase activity in NWS and SWS. Catalase and peroxidase activities were considerably higher in NWS and SWS of HT patients, while the concentrations of reduced glutathione and uric acid were significantly lower in comparison with healthy subjects. Total antioxidant potential was significantly lower, while total oxidant status and the level of oxidation products of proteins (advanced glycation end products, advanced oxidation protein products) and lipids (malondialdehyde, lipid hydroperoxides) were significantly higher in NWS, SWS and plasma of HT patients. In conclusion, in both salivary glands of women with HT in euthyreosis, the ability to maintain redox homeostasis was hindered. In HT patients we observed oxidative damage to salivary proteins and lipids; thus, some biomarkers of oxidative stress may present a potential diagnostic value.</description><subject>Antioxidants</subject><subject>Autoimmune diseases</subject><subject>Clinical medicine</subject><subject>Diabetes</subject><subject>Disease</subject><subject>Exocrine glands</subject><subject>Hormones</subject><subject>Lupus</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Patients</subject><subject>Plasma</subject><subject>Psoriasis</subject><subject>Rheumatoid arthritis</subject><subject>Thyroid gland</subject><subject>Womens health</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpdkc1KxDAQx4MorqxefIKAFxFW89E2yUUQWT9gwYOKx5i2UzdLm2jSLnrzNXw9n8TIil9zmWHmx5_5zyC0S8kh54ocLapOEcEoYWtoixEhJoRLvv6rHqGdGBckhZQZo2ITjTgreM4l20L3Uzc3roIaX5vWLk14wcbV-BwcBNPiq2dbm94uAV_3AWLE1uELE-e2871_f32L-Gb-ErytbW8jvvMduE9kOvSpDT7auI02GtNG2PnKY3R7Nr05vZjMrs4vT09mk4pT3k8oYyQnsuEko6UwtFBMKNlkQmWCFFQZ2RRCUlpCkRsKFQNW1mUNwBWXlQE-Rscr3ceh7KCuwPXJgH4MtkumtDdW_504O9cPfqlFRqRiPAnsfwkE_zRA7HVnYwVtaxz4IWqWbpflStAsoXv_0IUfgkv2NCsySnNCmEzUwYqqgo8xQPO9DCX683f653f8A8yPi90</recordid><startdate>20200703</startdate><enddate>20200703</enddate><creator>Morawska, Katarzyna</creator><creator>Maciejczyk, Mateusz</creator><creator>Popławski, Łukasz</creator><creator>Popławska-Kita, Anna</creator><creator>Krętowski, Adam</creator><creator>Zalewska, Anna</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5609-3187</orcidid><orcidid>https://orcid.org/0000-0003-4562-0951</orcidid><orcidid>https://orcid.org/0000-0002-4522-4978</orcidid></search><sort><creationdate>20200703</creationdate><title>Enhanced Salivary and General Oxidative Stress in Hashimoto’s Thyroiditis Women in Euthyreosis</title><author>Morawska, Katarzyna ; Maciejczyk, Mateusz ; Popławski, Łukasz ; Popławska-Kita, Anna ; Krętowski, Adam ; Zalewska, Anna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-1220508f3041b7a1692798f479470619a8f67811be65a1ec2e2bdbdee3938cae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antioxidants</topic><topic>Autoimmune diseases</topic><topic>Clinical medicine</topic><topic>Diabetes</topic><topic>Disease</topic><topic>Exocrine glands</topic><topic>Hormones</topic><topic>Lupus</topic><topic>Oxidation</topic><topic>Oxidative stress</topic><topic>Patients</topic><topic>Plasma</topic><topic>Psoriasis</topic><topic>Rheumatoid arthritis</topic><topic>Thyroid gland</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morawska, Katarzyna</creatorcontrib><creatorcontrib>Maciejczyk, Mateusz</creatorcontrib><creatorcontrib>Popławski, Łukasz</creatorcontrib><creatorcontrib>Popławska-Kita, Anna</creatorcontrib><creatorcontrib>Krętowski, Adam</creatorcontrib><creatorcontrib>Zalewska, Anna</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morawska, Katarzyna</au><au>Maciejczyk, Mateusz</au><au>Popławski, Łukasz</au><au>Popławska-Kita, Anna</au><au>Krętowski, Adam</au><au>Zalewska, Anna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced Salivary and General Oxidative Stress in Hashimoto’s Thyroiditis Women in Euthyreosis</atitle><jtitle>Journal of clinical medicine</jtitle><date>2020-07-03</date><risdate>2020</risdate><volume>9</volume><issue>7</issue><spage>2102</spage><pages>2102-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Hashimoto’s thyroiditis (HT) is one of the most common autoimmune diseases. Although HT is inextricably linked to oxidative stress, there have been no studies assessing salivary redox homeostasis or salivary gland function in patients with HT. This study is the first to compare antioxidant defense and oxidative stress biomarkers in non-stimulated (NWS) and stimulated (SWS) whole saliva and plasma/erythrocytes of HT patients compared to controls. The study included 45 women with HT in the euthyreosis period as well as an age- and gender-matched control group. We showed that NWS secretion was significantly lower in HT patients compared to healthy controls, similar to salivary amylase activity in NWS and SWS. Catalase and peroxidase activities were considerably higher in NWS and SWS of HT patients, while the concentrations of reduced glutathione and uric acid were significantly lower in comparison with healthy subjects. Total antioxidant potential was significantly lower, while total oxidant status and the level of oxidation products of proteins (advanced glycation end products, advanced oxidation protein products) and lipids (malondialdehyde, lipid hydroperoxides) were significantly higher in NWS, SWS and plasma of HT patients. In conclusion, in both salivary glands of women with HT in euthyreosis, the ability to maintain redox homeostasis was hindered. In HT patients we observed oxidative damage to salivary proteins and lipids; thus, some biomarkers of oxidative stress may present a potential diagnostic value.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>32635382</pmid><doi>10.3390/jcm9072102</doi><orcidid>https://orcid.org/0000-0001-5609-3187</orcidid><orcidid>https://orcid.org/0000-0003-4562-0951</orcidid><orcidid>https://orcid.org/0000-0002-4522-4978</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Antioxidants Autoimmune diseases Clinical medicine Diabetes Disease Exocrine glands Hormones Lupus Oxidation Oxidative stress Patients Plasma Psoriasis Rheumatoid arthritis Thyroid gland Womens health |
title | Enhanced Salivary and General Oxidative Stress in Hashimoto’s Thyroiditis Women in Euthyreosis |
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