Multi-Epitope Peptide-Based and Vaccinia-Based Universal Influenza Vaccine Candidates Subjected to Clinical Trials

[...]strategies, such as combining peptides as multi-epitope vaccines or presenting peptides on vaccinia virus particles, are employed. On top of that, predicting the strains that must be included in the formulation of vaccines for combating upcoming influenza outbreaks is difficult owing to gene mu...

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Bibliographic Details
Published in:The Malaysian journal of medical sciences 2020-03, Vol.27 (2), p.10-20
Main Authors: Romeli, Syazwani, Syed Hassan, Sharifah, Yap, Wei Boon
Format: Article
Language:English
Subjects:
Antigens
Clinical trials
Infections
Influenza
Medical research
Pandemics
Peptides
Proteins
Review
Vaccines
Viral infections
Viruses
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Summary:[...]strategies, such as combining peptides as multi-epitope vaccines or presenting peptides on vaccinia virus particles, are employed. On top of that, predicting the strains that must be included in the formulation of vaccines for combating upcoming influenza outbreaks is difficult owing to gene mutations through antigenic drift and shift patterns in influenza viruses (4). [...]the use of hemagglutinin (HA) (5) as the antigen of choice in the present vaccine formulation and the classic manner of producing influenza vaccine in embryonated chicken eggs reduce the efficacy of influenza vaccines (6). [...]its antigenicity is altered and the stimulation of humoral responses that inhibit the binding of virus to host cells is limited. The triepitope peptide vaccine provided greater protection than the single epitope. [...]the immune responses induced by the triepitope peptide vaccine lasted longer and were able to protect vaccinated mice challenged with influenza virus seven months since the last boost (18).
ISSN:1394-195X
2180-4303
DOI:10.21315/mjms2020.27.2.2