Metabolic radiogenomics in lung cancer: associations between FDG PET image features and oncogenic signaling pathway alterations

This study investigated the associations between image features extracted from tumor 18 F-fluorodeoxyglucose (FDG) uptake and genetic alterations in patients with lung cancer. A total of 137 patients (age, 62.7 ± 10.2 years) who underwent FDG positron emission tomography/computed tomography (PET/CT)...

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Bibliographic Details
Published in:Scientific reports 2020-08, Vol.10 (1), p.13231-13231, Article 13231
Main Authors: Kim, Gahyun, Kim, Jinho, Cha, Hongui, Park, Woong-Yang, Ahn, Jin Seok, Ahn, Myung-Ju, Park, Keunchil, Park, Yong-Jin, Choi, Joon Young, Lee, Kyung-Han, Lee, Se-Hoon, Moon, Seung Hwan
Format: Article
Language:English
Subjects:
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Adenocarcinoma
Adenocarcinoma of Lung - diagnostic imaging
Adenocarcinoma of Lung - genetics
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell - diagnostic imaging
Carcinoma, Squamous Cell - genetics
Cell cycle
Computed tomography
Female
Fluorodeoxyglucose F18 - administration & dosage
Gene Regulatory Networks
High-Throughput Nucleotide Sequencing
Humanities and Social Sciences
Humans
Lesions
Lung cancer
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - genetics
Male
Middle Aged
multidisciplinary
Mutation
p53 Protein
Positron emission tomography
Positron Emission Tomography Computed Tomography
Radiographic Image Interpretation, Computer-Assisted
Science
Science (multidisciplinary)
Sequence analysis
Sequence Analysis, DNA - methods
Signal transduction
Small cell lung carcinoma
Small Cell Lung Carcinoma - diagnostic imaging
Small Cell Lung Carcinoma - genetics
Squamous cell carcinoma
Tomography
Wnt protein
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Summary:This study investigated the associations between image features extracted from tumor 18 F-fluorodeoxyglucose (FDG) uptake and genetic alterations in patients with lung cancer. A total of 137 patients (age, 62.7 ± 10.2 years) who underwent FDG positron emission tomography/computed tomography (PET/CT) and targeted deep sequencing analysis for a tumor lesion, comprising 61 adenocarcinoma (ADC), 31 squamous cell carcinoma (SQCC), and 45 small cell lung cancer (SCLC) patients, were enrolled in this study. From the tumor lesions, 86 image features were extracted, and 381 genes were assessed. PET features were associated with genetic mutations: 41 genes with 24 features in ADC; 35 genes with 22 features in SQCC; and 43 genes with 25 features in SCLC (FDR 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-70168-x