Endoplasmic Reticulum Stress (ER Stress) and Unfolded Protein Response (UPR) Occur in a Rat Varicocele Testis Model

Using a surgically induced varicocele rat model, we show here strong evidence that the misfolded/unfolded protein response that is part of the stress response of the endoplasmic reticulum (ER) is activated in the varicocele testis (VCL), leading to the induction of apoptosis. To support this hypothe...

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Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2020, Vol.2020 (2020), p.1-11
Main Authors: Nasr-Esfahani, Mohammad H., Drevet, J. R., Tavalaee, Marziyeh, Golsefid, Aram Ahmadzadeh, Eskandari, Anahita, Rahmani, Mohsen, Shaygannia, Erfaneh, Hosseini, Mahshid, Gharagozloo, Parviz
Format: Article
Language:English
Subjects:
Animals
Antibodies
Apoptosis
Deoxyribonucleic acid
Development Biology
Disease Models, Animal
DNA
DNA damage
Endoplasmic reticulum
Endoplasmic Reticulum Stress - genetics
Gametogenesis
Humans
Immunoglobulins
Infertility
Life Sciences
Lipid peroxidation
Lipids
Male
Morphology
Oxidative stress
Proteins
Rats
Reproductive Biology
Sexual reproduction
Sperm
Spermatogenesis
Testis - metabolism
Transcription factors
Unfolded Protein Response - genetics
Varicocele - metabolism
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Summary:Using a surgically induced varicocele rat model, we show here strong evidence that the misfolded/unfolded protein response that is part of the stress response of the endoplasmic reticulum (ER) is activated in the varicocele testis (VCL), leading to the induction of apoptosis. To support this hypothesis, it is observed that the spliced variant of the X-box protein 1 (XBP1s), resulting from the activation of the inositol-requiring enzyme 1 (IRE1) membrane sensor, is significantly more represented in VCL testicular extracts. The activation of the IRE1/XBP1s pathway is also supported by the observation that the VCL testes show an increase phosphorylation of the c-Jun-kinase (JNK) known to be one intermediate of this pathway and an increased level of caspase-3, the terminal apoptotic effector, partly explaining the apoptotic status of the VCL testis.
ISSN:1942-0900
1942-0994
DOI:10.1155/2020/5909306