Influence of dl-3-N-butylphthalide on infarction size in rats with acute myocardial infarction

OBJECTIVETo study the influence of dl-3-N-butylphthalide (NBP) on infarction size in rats with acute myocardial infarction (AMI). METHODSAMI model was established by ligation of the left anterior descending artery. A total of 36 healthy male Sprague-Dawley rats (weight, 180 t, 180 ght, 180 ligation...

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Published in:International journal of clinical and experimental pathology 2020-01, Vol.13 (7), p.1707-1711
Main Authors: Wang, Yanbo, Hao, Guozhen, Jiang, Yunfa, Zhi, Wei, Wang, Qing, Gu, Xinshun
Format: Article
Language:English
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Summary:OBJECTIVETo study the influence of dl-3-N-butylphthalide (NBP) on infarction size in rats with acute myocardial infarction (AMI). METHODSAMI model was established by ligation of the left anterior descending artery. A total of 36 healthy male Sprague-Dawley rats (weight, 180 t, 180 ght, 180 ligation of left anterior descending artery. A total of 36 healthy males were assigned to model group, sham-operation (SO) group, and the NBP group (n=12 each). The rats in the NBP group were treated with intraperitoneal injection administration of 60 mg/kg/body weight NBP once a day. The rats in the other groups were given distilled water of the same volume. The MI area in each group was detected by TTC staining. The concentrations of CK-MB and LDH were detected. The concentrations of TNF-α, IL-6, MDA, and SOD were measured by ELISA. RESULTSCompared with the SO group, the myocardial infarct sizes in the model group and the NBP group were significantly increased (P
ISSN:1936-2625