The RDoC approach for translational psychiatry: Could a genetic disorder with psychiatric symptoms help fill the matrix? the example of Prader–Willi syndrome

The Research Domain Criteria project (RDoc) proposes a new classification system based on information from several fields in order to encourage translational perspectives. Nevertheless, integrating genetic markers into this classification has remained difficult because of the lack of powerful associ...

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Bibliographic Details
Published in:Translational psychiatry 2020-08, Vol.10 (1), p.274-274, Article 274
Main Authors: Salles, Juliette, Lacassagne, Emmanuelle, Benvegnu, Grégoire, Berthoumieu, Sophie Çabal, Franchitto, Nicolas, Tauber, Maithé
Format: Article
Language:English
Subjects:
692/420/2489
692/699/476/5
Behavioral Sciences
Biological Psychology
Brain / diagnostic imaging
Genes
Genetic disorders
Human health and pathology
Humans
Infectious diseases
Life Sciences
Medicine
Medicine & Public Health
Mental Disorders / genetics
Neurosciences
Pharmacotherapy
Prader-Willi Syndrome / genetics
Psychiatry
Research Design
Review
Review Article
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Summary:The Research Domain Criteria project (RDoc) proposes a new classification system based on information from several fields in order to encourage translational perspectives. Nevertheless, integrating genetic markers into this classification has remained difficult because of the lack of powerful associations between targeted genes and RDoC domains. We hypothesized that genetic diseases with psychiatric manifestations would be good models for RDoC gene investigations and would thereby extend the translational approach to involve targeted gene pathways. To explore this possibility, we reviewed the current knowledge on Prader–Willi syndrome, a genetic disorder caused by the absence of expression of some of the genes of the chromosome 15q11–13 region inherited from the father. Indeed, we found that the associations between genes of the PW locus and the modification identified in the relevant behavioral, physiological, and brain imaging studies followed the structure of the RDoC matrix and its six domains (positive valence, negative valence, social processing, cognitive systems, arousal/regulatory systems, and sensorimotor systems).
ISSN:2158-3188
2158-3188
DOI:10.1038/s41398-020-00964-6