Antifungal prophylaxis in lung transplant recipients: A systematic review and meta‐analysis

Background No consensus exists regarding optimal strategy for antifungal prophylaxis following lung transplant. Objective To review data regarding antifungal prophylaxis on the development of fungal infections. Study selection/Appraisal We searched MEDLINE, Embase, and Scopus for eligible articles t...

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Bibliographic Details
Published in:Transplant infectious disease 2020-08, Vol.22 (4), p.e13333-n/a
Main Authors: Pennington, Kelly M., Baqir, Misbah, Erwin, Patricia J., Razonable, Raymund R., Murad, Mohammad Hassan, Kennedy, Cassie C.
Format: Article
Language:English
Subjects:
Antifungal Agents - therapeutic use
aspergillus
Chemoprevention - methods
fungal infection
Fungal infections
Fungi
Fungicides
Humans
Immunocompromised Host
Infections
Lung - drug effects
Lung - microbiology
lung transplant
Lung transplantation
Lung Transplantation - adverse effects
Lung transplants
Lungs
Meta-analysis
Mycoses - prevention & control
Preempting
Prophylaxis
Transplant Recipients
Transplantation, Homologous - adverse effects
Treatment Outcome
Triazoles
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Summary:Background No consensus exists regarding optimal strategy for antifungal prophylaxis following lung transplant. Objective To review data regarding antifungal prophylaxis on the development of fungal infections. Study selection/Appraisal We searched MEDLINE, Embase, and Scopus for eligible articles through December 10, 2019. Observational or controlled trials published after January 1, 2001, that pertained to the prevention of fungal infections in adult lung recipients were reviewed independently by two reviewers for inclusion. Methods Of 1702 articles screened, 24 were included. Data were pooled using random effects model to evaluate for the primary outcome of fungal infection. Studies were stratified by prophylactic strategy, medication, and duration (short term 
ISSN:1398-2273
1399-3062
DOI:10.1111/tid.13333