Gene Expression Network Analysis of Precursor Lesions in Familial Pancreatic Cancer

High-grade pancreatic intraepithelial neoplasia (PanIN) are aggressive premalignant lesions, associated with risk of progression to pancreatic ductal adenocarcinoma (PDAC). A depiction of co-dysregulated gene activity in high-grade familial pancreatic cancer (FPC)-related PanIN lesions may character...

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Bibliographic Details
Published in:Journal of pancreatic cancer 2020-08, Vol.6 (1), p.73-84
Main Authors: Tan, Ming, Schaffalitzky de Muckadell, Ove B, Jøergensen, Maiken Thyregod
Format: Article
Language:English
Subjects:
Age
Gene expression
Original
Pancreatic cancer
Patients
Principal components analysis
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Summary:High-grade pancreatic intraepithelial neoplasia (PanIN) are aggressive premalignant lesions, associated with risk of progression to pancreatic ductal adenocarcinoma (PDAC). A depiction of co-dysregulated gene activity in high-grade familial pancreatic cancer (FPC)-related PanIN lesions may characterize the molecular events during the progression from familial PanIN to PDAC. We performed weighted gene coexpression network analysis (WGCNA) to identify clusters of coexpressed genes associated with FPC-related PanIN lesions in 13 samples with PanIN-2/3 from FPC predisposed individuals, 6 samples with PDAC from sporadic pancreatic cancer (SPC) patients, and 4 samples of normal donor pancreatic tissue. WGCNA identified seven differentially expressed gene (DEG) modules and two commonly expressed gene (CEG) modules with significant enrichment for Gene Ontology (GO) terms in FPC and SPC, including three upregulated (  
ISSN:2475-3246
2475-3246
DOI:10.1089/pancan.2020.0007