Association of plasma exosomes with severity of organ failure and mortality in patients with sepsis

Current sepsis biomarkers may be helpful in determining organ failure and evaluating patient clinical course; however, direct molecular biomarkers to predict subsequent organ failure have not yet been discovered. Exosomes, a small population of extracellular vesicles, play an important role in the i...

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Bibliographic Details
Published in:Journal of cellular and molecular medicine 2020-08, Vol.24 (16), p.9439-9445
Main Authors: Im, Yunjoo, Yoo, Hongseok, Lee, Jin Young, Park, Junseon, Suh, Gee Young, Jeon, Kyeongman
Format: Article
Language:English
Subjects:
biomarker
Biomarkers
Cytokines
Exosomes
Extracellular vesicles
Hospitals
Illnesses
Inflammation
Informed consent
Mortality
organ failure
Original
Pathophysiology
Patients
Physiology
Plasma
Proteins
Sepsis
Septic shock
Studies
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Summary:Current sepsis biomarkers may be helpful in determining organ failure and evaluating patient clinical course; however, direct molecular biomarkers to predict subsequent organ failure have not yet been discovered. Exosomes, a small population of extracellular vesicles, play an important role in the inflammatory response, coagulation process and cardiac dysfunction in sepsis. Nonetheless, the association of plasma exosome with severity and mortality of sepsis is not well known. Therefore, the overall levels of plasma exosome in sepsis patients were assessed and whether exosome levels were associated with organ failure and mortality was evaluated in the present study. Plasma level of exosomes was measured by ELISA. Among 220 patients with sepsis, 145 (66%) patients were diagnosed with septic shock. A trend of increased exosome levels in control, sepsis and septic shock groups was observed (204 µg/mL vs 525 µg/mL vs 802 µg/mL, P 
ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.15606