Extensive cerebral venous sinus thrombosis: a potential complication in a patient with COVID-19 disease

A 63-year-old man was admitted with left-sided weakness and subsequent focal seizures following a recent diagnosis of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia in a nearby hospital. He developed status epilepticus and became comatose, requiring intensive care unit admiss...

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Bibliographic Details
Published in:BMJ case reports 2020-08, Vol.13 (8), p.e236820
Main Authors: Bolaji, Paul, Kukoyi, Babatunde, Ahmad, Nasar, Wharton, Chris
Format: Article
Language:English
Subjects:
Antibodies
Anticoagulants
Anticoagulants - therapeutic use
Betacoronavirus
Blood tests
Case reports
Coma
Coronavirus Infections - complications
Coronaviruses
COVID-19
Cranial Sinuses - diagnostic imaging
Cytokines
Defects
Humans
Infections
Male
Medical imaging
Middle Aged
Mutation
Pandemics
Patients
Pneumonia
Pneumonia, Viral - complications
Proteins
Rehabilitation
Risk factors
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Sinus Thrombosis, Intracranial - diagnostic imaging
Sinus Thrombosis, Intracranial - drug therapy
Sinus Thrombosis, Intracranial - etiology
Sinuses
Stroke
Thromboembolism
Thrombosis
Tomography, X-Ray Computed - methods
Unusual Association of Diseases/Symptoms
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Summary:A 63-year-old man was admitted with left-sided weakness and subsequent focal seizures following a recent diagnosis of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia in a nearby hospital. He developed status epilepticus and became comatose, requiring intensive care unit admission for invasive ventilation. Imaging done at admission confirmed extensive cerebral venous sinus thrombosis (CVST) with bilateral venous cortical infarcts and acute cortical haemorrhage. No known risk factor for CVST could be identified. He improved with anticoagulation and antiepileptic therapy. He was subsequently transferred to an inpatient rehabilitation facility. Although Coronavirus disease 19 (COVID-19) infection has been previously associated with thrombotic complications, these mostly relate to the pulmonary vasculature. We present this case as a potential association between CVST and COVID-19 infection.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2020-236820