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Assessment of GSTO1 (A140D) and GSTO2 (N142D) Gene Polymorphisms in Iranian Women with Polycystic Ovarian Syndrome
Glutathione S-transferases (GSTs) protect cells from oxidative stress (OS). In humans, the GST omega class contains two expressed genes, and . Because OS is involved in the pathogenesis of polycystic ovary syndrome (PCOS), the aim of this study was to investigate the relationship between A140D (rs49...
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| Published in: | Reports of biochemistry and molecular biology 2020-04, Vol.9 (1), p.8-13 |
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| creator | Miraghaee, Seyyed Shahram Sohrabi, Maryam Jalili, Cyrus Bahrehmand, Fariborz |
| description | Glutathione S-transferases (GSTs) protect cells from oxidative stress (OS). In humans, the GST omega class contains two expressed genes,
and
. Because OS is involved in the pathogenesis of polycystic ovary syndrome (PCOS), the aim of this study was to investigate the relationship between
A140D (rs4925) and
N142D (rs156697) polymorphisms in PCOS patients.
175 PCOS patients and 161 healthy controls were selected among women in Kermanshah province, Iran.
and
were genotyped using allele-specific PCR (AS-PCR) and PCR-RFLP, respectively.
For
, the DD genotype and the D allele led to 2.17- (
= 0.02) and 1.5-fold (P= 0.01) increases, respectively, in the odds ratios for PCOS. No significant difference was found between control and patient groups for the
N142D genotype or allele frequency. GSTO1 and GSTO2 genotype interaction analysis showed that individuals with the
AD or DD genotypes and the GSTO2 NN or DN genotypes had a 1.53-fold (
= 0.007) increase in PCOS risk over
AA and GSTO2 DD individuals.
The
A140D polymorphism is a risk factor for PCOS. |
| doi_str_mv | 10.29252/rbmb.9.1.8 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7424423</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2436394281</sourcerecordid><originalsourceid>FETCH-LOGICAL-c381t-a1716236dec331a36b180de79fe607dfddb06315b27e7e4ffa9cc09f5bef1df33</originalsourceid><addsrcrecordid>eNpVkc1rGzEQxUVpaEKaU-9FR5diVzOStbuXgkkTNxDqQlJ6FFp91Cq7kiutE_zfZ-2kITnNMO_HmxkeIR-AzbDBOX7Jbd_OmhnM6jfkBDnilIuavX3RH5OzUv4yxgDnUjbyHTnmWCNUQp6QvCjFldK7ONDk6fLmdgV0sgDBvn2iOtrDBOnkBwgcJ0sXHf2Zul2f8mYdSl9oiPQq6xh0pL_T6EPvw7A-MGZXhmDo6k7nvXqzizaPxHty5HVX3NlTPSW_Li9uz79Pr1fLq_PF9dTwGoaphgokcmmd4Rw0ly3UzLqq8U6yynprWyY5zFusXOWE97oxhjV-3joP1nN-Sr4--m62be-sGV_MulObHHqddyrpoF4rMazVn3SnKoFC4N5g8mSQ07-tK4PqQzGu63R0aVsUCi55I7CGEf38iJqcSsnOP68Bpg5BqX1QqlGg6pH--PKyZ_Z_LPwB272Ogw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2436394281</pqid></control><display><type>article</type><title>Assessment of GSTO1 (A140D) and GSTO2 (N142D) Gene Polymorphisms in Iranian Women with Polycystic Ovarian Syndrome</title><source>PubMed Central</source><creator>Miraghaee, Seyyed Shahram ; Sohrabi, Maryam ; Jalili, Cyrus ; Bahrehmand, Fariborz</creator><creatorcontrib>Miraghaee, Seyyed Shahram ; Sohrabi, Maryam ; Jalili, Cyrus ; Bahrehmand, Fariborz ; Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran ; Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran</creatorcontrib><description>Glutathione S-transferases (GSTs) protect cells from oxidative stress (OS). In humans, the GST omega class contains two expressed genes,
and
. Because OS is involved in the pathogenesis of polycystic ovary syndrome (PCOS), the aim of this study was to investigate the relationship between
A140D (rs4925) and
N142D (rs156697) polymorphisms in PCOS patients.
175 PCOS patients and 161 healthy controls were selected among women in Kermanshah province, Iran.
and
were genotyped using allele-specific PCR (AS-PCR) and PCR-RFLP, respectively.
For
, the DD genotype and the D allele led to 2.17- (
= 0.02) and 1.5-fold (P= 0.01) increases, respectively, in the odds ratios for PCOS. No significant difference was found between control and patient groups for the
N142D genotype or allele frequency. GSTO1 and GSTO2 genotype interaction analysis showed that individuals with the
AD or DD genotypes and the GSTO2 NN or DN genotypes had a 1.53-fold (
= 0.007) increase in PCOS risk over
AA and GSTO2 DD individuals.
The
A140D polymorphism is a risk factor for PCOS.</description><identifier>ISSN: 2322-3480</identifier><identifier>EISSN: 2322-3480</identifier><identifier>DOI: 10.29252/rbmb.9.1.8</identifier><identifier>PMID: 32821746</identifier><language>eng</language><publisher>Iran: Varastegan Institute for Medical Sciences</publisher><subject>Original</subject><ispartof>Reports of biochemistry and molecular biology, 2020-04, Vol.9 (1), p.8-13</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-a1716236dec331a36b180de79fe607dfddb06315b27e7e4ffa9cc09f5bef1df33</citedby><cites>FETCH-LOGICAL-c381t-a1716236dec331a36b180de79fe607dfddb06315b27e7e4ffa9cc09f5bef1df33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424423/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424423/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32821746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miraghaee, Seyyed Shahram</creatorcontrib><creatorcontrib>Sohrabi, Maryam</creatorcontrib><creatorcontrib>Jalili, Cyrus</creatorcontrib><creatorcontrib>Bahrehmand, Fariborz</creatorcontrib><creatorcontrib>Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran</creatorcontrib><creatorcontrib>Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran</creatorcontrib><title>Assessment of GSTO1 (A140D) and GSTO2 (N142D) Gene Polymorphisms in Iranian Women with Polycystic Ovarian Syndrome</title><title>Reports of biochemistry and molecular biology</title><addtitle>Rep Biochem Mol Biol</addtitle><description>Glutathione S-transferases (GSTs) protect cells from oxidative stress (OS). In humans, the GST omega class contains two expressed genes,
and
. Because OS is involved in the pathogenesis of polycystic ovary syndrome (PCOS), the aim of this study was to investigate the relationship between
A140D (rs4925) and
N142D (rs156697) polymorphisms in PCOS patients.
175 PCOS patients and 161 healthy controls were selected among women in Kermanshah province, Iran.
and
were genotyped using allele-specific PCR (AS-PCR) and PCR-RFLP, respectively.
For
, the DD genotype and the D allele led to 2.17- (
= 0.02) and 1.5-fold (P= 0.01) increases, respectively, in the odds ratios for PCOS. No significant difference was found between control and patient groups for the
N142D genotype or allele frequency. GSTO1 and GSTO2 genotype interaction analysis showed that individuals with the
AD or DD genotypes and the GSTO2 NN or DN genotypes had a 1.53-fold (
= 0.007) increase in PCOS risk over
AA and GSTO2 DD individuals.
The
A140D polymorphism is a risk factor for PCOS.</description><subject>Original</subject><issn>2322-3480</issn><issn>2322-3480</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpVkc1rGzEQxUVpaEKaU-9FR5diVzOStbuXgkkTNxDqQlJ6FFp91Cq7kiutE_zfZ-2kITnNMO_HmxkeIR-AzbDBOX7Jbd_OmhnM6jfkBDnilIuavX3RH5OzUv4yxgDnUjbyHTnmWCNUQp6QvCjFldK7ONDk6fLmdgV0sgDBvn2iOtrDBOnkBwgcJ0sXHf2Zul2f8mYdSl9oiPQq6xh0pL_T6EPvw7A-MGZXhmDo6k7nvXqzizaPxHty5HVX3NlTPSW_Li9uz79Pr1fLq_PF9dTwGoaphgokcmmd4Rw0ly3UzLqq8U6yynprWyY5zFusXOWE97oxhjV-3joP1nN-Sr4--m62be-sGV_MulObHHqddyrpoF4rMazVn3SnKoFC4N5g8mSQ07-tK4PqQzGu63R0aVsUCi55I7CGEf38iJqcSsnOP68Bpg5BqX1QqlGg6pH--PKyZ_Z_LPwB272Ogw</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Miraghaee, Seyyed Shahram</creator><creator>Sohrabi, Maryam</creator><creator>Jalili, Cyrus</creator><creator>Bahrehmand, Fariborz</creator><general>Varastegan Institute for Medical Sciences</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200401</creationdate><title>Assessment of GSTO1 (A140D) and GSTO2 (N142D) Gene Polymorphisms in Iranian Women with Polycystic Ovarian Syndrome</title><author>Miraghaee, Seyyed Shahram ; Sohrabi, Maryam ; Jalili, Cyrus ; Bahrehmand, Fariborz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-a1716236dec331a36b180de79fe607dfddb06315b27e7e4ffa9cc09f5bef1df33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Original</topic><toplevel>online_resources</toplevel><creatorcontrib>Miraghaee, Seyyed Shahram</creatorcontrib><creatorcontrib>Sohrabi, Maryam</creatorcontrib><creatorcontrib>Jalili, Cyrus</creatorcontrib><creatorcontrib>Bahrehmand, Fariborz</creatorcontrib><creatorcontrib>Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran</creatorcontrib><creatorcontrib>Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Reports of biochemistry and molecular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miraghaee, Seyyed Shahram</au><au>Sohrabi, Maryam</au><au>Jalili, Cyrus</au><au>Bahrehmand, Fariborz</au><aucorp>Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran</aucorp><aucorp>Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of GSTO1 (A140D) and GSTO2 (N142D) Gene Polymorphisms in Iranian Women with Polycystic Ovarian Syndrome</atitle><jtitle>Reports of biochemistry and molecular biology</jtitle><addtitle>Rep Biochem Mol Biol</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>9</volume><issue>1</issue><spage>8</spage><epage>13</epage><pages>8-13</pages><issn>2322-3480</issn><eissn>2322-3480</eissn><abstract>Glutathione S-transferases (GSTs) protect cells from oxidative stress (OS). In humans, the GST omega class contains two expressed genes,
and
. Because OS is involved in the pathogenesis of polycystic ovary syndrome (PCOS), the aim of this study was to investigate the relationship between
A140D (rs4925) and
N142D (rs156697) polymorphisms in PCOS patients.
175 PCOS patients and 161 healthy controls were selected among women in Kermanshah province, Iran.
and
were genotyped using allele-specific PCR (AS-PCR) and PCR-RFLP, respectively.
For
, the DD genotype and the D allele led to 2.17- (
= 0.02) and 1.5-fold (P= 0.01) increases, respectively, in the odds ratios for PCOS. No significant difference was found between control and patient groups for the
N142D genotype or allele frequency. GSTO1 and GSTO2 genotype interaction analysis showed that individuals with the
AD or DD genotypes and the GSTO2 NN or DN genotypes had a 1.53-fold (
= 0.007) increase in PCOS risk over
AA and GSTO2 DD individuals.
The
A140D polymorphism is a risk factor for PCOS.</abstract><cop>Iran</cop><pub>Varastegan Institute for Medical Sciences</pub><pmid>32821746</pmid><doi>10.29252/rbmb.9.1.8</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Original |
| title | Assessment of GSTO1 (A140D) and GSTO2 (N142D) Gene Polymorphisms in Iranian Women with Polycystic Ovarian Syndrome |
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