Myocyte-Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2–Mediated Myocarditis

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2020-08, Vol.142 (7), p.708-710, Article CIRCULATIONAHA.120.047911
Main Authors: Tucker, Nathan R., Chaffin, Mark, Bedi, Kenneth C., Papangeli, Irinna, Akkad, Amer-Denis, Arduini, Alessandro, Hayat, Sikander, Eraslan, Gökcen, Muus, Christoph, Bhattacharyya, Roby P., Stegmann, Christian M., Margulies, Kenneth B., Ellinor, Patrick T.
Format: Article
Language:English
Subjects:
Angiotensin-Converting Enzyme 2
Betacoronavirus - isolation & purification
Betacoronavirus - pathogenicity
Cardiomyopathy, Dilated - genetics
Cardiomyopathy, Dilated - pathology
Cardiomyopathy, Hypertrophic - genetics
Cardiomyopathy, Hypertrophic - pathology
Cathepsin L - genetics
Cathepsin L - metabolism
Coronavirus Infections - complications
Coronavirus Infections - pathology
Coronavirus Infections - virology
Correspondence
COVID-19
Heart Ventricles - metabolism
Humans
Life Sciences
Myocarditis - diagnosis
Myocarditis - etiology
Myocardium - metabolism
Pandemics
Peptidyl-Dipeptidase A - chemistry
Peptidyl-Dipeptidase A - genetics
Peptidyl-Dipeptidase A - metabolism
Pneumonia, Viral - complications
Pneumonia, Viral - pathology
Pneumonia, Viral - virology
Protease Inhibitors - pharmacology
RNA-Seq
SARS-CoV-2
Serine Endopeptidases - genetics
Serine Endopeptidases - metabolism
Up-Regulation - drug effects
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Summary:Supplemental Digital Content is available in the text.
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.120.047911