Loading…

Myocyte-Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2–Mediated Myocarditis

Supplemental Digital Content is available in the text.

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2020-08, Vol.142 (7), p.708-710, Article CIRCULATIONAHA.120.047911
Main Authors: Tucker, Nathan R., Chaffin, Mark, Bedi, Kenneth C., Papangeli, Irinna, Akkad, Amer-Denis, Arduini, Alessandro, Hayat, Sikander, Eraslan, Gökcen, Muus, Christoph, Bhattacharyya, Roby P., Stegmann, Christian M., Margulies, Kenneth B., Ellinor, Patrick T.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c6061-c2778cb876ec85801d1ae9f6fe0b6619967a67967a88cfb828fa4997648f5a623
cites cdi_FETCH-LOGICAL-c6061-c2778cb876ec85801d1ae9f6fe0b6619967a67967a88cfb828fa4997648f5a623
container_end_page 710
container_issue 7
container_start_page 708
container_title Circulation (New York, N.Y.)
container_volume 142
creator Tucker, Nathan R.
Chaffin, Mark
Bedi, Kenneth C.
Papangeli, Irinna
Akkad, Amer-Denis
Arduini, Alessandro
Hayat, Sikander
Eraslan, Gökcen
Muus, Christoph
Bhattacharyya, Roby P.
Stegmann, Christian M.
Margulies, Kenneth B.
Ellinor, Patrick T.
description Supplemental Digital Content is available in the text.
doi_str_mv 10.1161/CIRCULATIONAHA.120.047911
format article
fullrecord <record><control><sourceid>pubmed_hal_p</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7424896</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>32795091</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6061-c2778cb876ec85801d1ae9f6fe0b6619967a67967a88cfb828fa4997648f5a623</originalsourceid><addsrcrecordid>eNpdkc1uEzEUhS0EoqHwCsgsWTjYnhn_sEAaTQuJlFKpadhajmM3hkk8siepsuMdeEOeBA8DFWVzrXvvOeda-gB4Q_CUEEbeNfObZrWob-fXn-tZPSUUT3HJJSFPwIRUtERlVcinYIIxlogXlJ6BFyl9zS0rePUcnBWUywpLMgHp6hTMqbdo2VnjnTdw1UV7d2h178MeBgfr5pJCv4eNjhsfjjqZvIzwwierk30P57uu9ea3PEEXIlzWN0vUhC-I_vz-48puvO7tBg53hoTep5fgmdNtsq_-vOdg9fHytpmhxfWneVMvkGGYEWQo58KsBWfWiEpgsiHaSsecxWvGiJSMa8aHKoRxa0GF06WUnJXCVZrR4hx8GHO7w3pnN8bu-6hb1UW_0_Gkgvbq8Wbvt-ouHBUvaSkkywFvx4Dtf7ZZvVDDDFMpaYHZkWStHLUmhpSidQ8GgtVATT2mpjI1NVLL3tf_fvTB-RdTFpSj4D60vY3pW3u4t1FtrW77rcpccYEJRxRTjAURGOVJzv0FEY-l9w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Myocyte-Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2–Mediated Myocarditis</title><source>EZB Electronic Journals Library</source><creator>Tucker, Nathan R. ; Chaffin, Mark ; Bedi, Kenneth C. ; Papangeli, Irinna ; Akkad, Amer-Denis ; Arduini, Alessandro ; Hayat, Sikander ; Eraslan, Gökcen ; Muus, Christoph ; Bhattacharyya, Roby P. ; Stegmann, Christian M. ; Margulies, Kenneth B. ; Ellinor, Patrick T.</creator><creatorcontrib>Tucker, Nathan R. ; Chaffin, Mark ; Bedi, Kenneth C. ; Papangeli, Irinna ; Akkad, Amer-Denis ; Arduini, Alessandro ; Hayat, Sikander ; Eraslan, Gökcen ; Muus, Christoph ; Bhattacharyya, Roby P. ; Stegmann, Christian M. ; Margulies, Kenneth B. ; Ellinor, Patrick T. ; Human Cell Atlas Lung Biological Network Consortium Members ; Human Cell Atlas Lung Biological Network</creatorcontrib><description>Supplemental Digital Content is available in the text.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/CIRCULATIONAHA.120.047911</identifier><identifier>PMID: 32795091</identifier><language>eng</language><publisher>United States: by the American College of Cardiology Foundation and the American Heart Association, Inc</publisher><subject>Angiotensin-Converting Enzyme 2 ; Betacoronavirus - isolation &amp; purification ; Betacoronavirus - pathogenicity ; Cardiomyopathy, Dilated - genetics ; Cardiomyopathy, Dilated - pathology ; Cardiomyopathy, Hypertrophic - genetics ; Cardiomyopathy, Hypertrophic - pathology ; Cathepsin L - genetics ; Cathepsin L - metabolism ; Coronavirus Infections - complications ; Coronavirus Infections - pathology ; Coronavirus Infections - virology ; Correspondence ; COVID-19 ; Heart Ventricles - metabolism ; Humans ; Life Sciences ; Myocarditis - diagnosis ; Myocarditis - etiology ; Myocardium - metabolism ; Pandemics ; Peptidyl-Dipeptidase A - chemistry ; Peptidyl-Dipeptidase A - genetics ; Peptidyl-Dipeptidase A - metabolism ; Pneumonia, Viral - complications ; Pneumonia, Viral - pathology ; Pneumonia, Viral - virology ; Protease Inhibitors - pharmacology ; RNA-Seq ; SARS-CoV-2 ; Serine Endopeptidases - genetics ; Serine Endopeptidases - metabolism ; Up-Regulation - drug effects</subject><ispartof>Circulation (New York, N.Y.), 2020-08, Vol.142 (7), p.708-710, Article CIRCULATIONAHA.120.047911</ispartof><rights>by the American College of Cardiology Foundation and the American Heart Association, Inc.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2020 American Heart Association, Inc. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6061-c2778cb876ec85801d1ae9f6fe0b6619967a67967a88cfb828fa4997648f5a623</citedby><cites>FETCH-LOGICAL-c6061-c2778cb876ec85801d1ae9f6fe0b6619967a67967a88cfb828fa4997648f5a623</cites><orcidid>0000-0002-8093-4465 ; 0000-0002-2067-0533 ; 0000-0001-6955-5088 ; 0000-0001-9632-6483</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32795091$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02992306$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Tucker, Nathan R.</creatorcontrib><creatorcontrib>Chaffin, Mark</creatorcontrib><creatorcontrib>Bedi, Kenneth C.</creatorcontrib><creatorcontrib>Papangeli, Irinna</creatorcontrib><creatorcontrib>Akkad, Amer-Denis</creatorcontrib><creatorcontrib>Arduini, Alessandro</creatorcontrib><creatorcontrib>Hayat, Sikander</creatorcontrib><creatorcontrib>Eraslan, Gökcen</creatorcontrib><creatorcontrib>Muus, Christoph</creatorcontrib><creatorcontrib>Bhattacharyya, Roby P.</creatorcontrib><creatorcontrib>Stegmann, Christian M.</creatorcontrib><creatorcontrib>Margulies, Kenneth B.</creatorcontrib><creatorcontrib>Ellinor, Patrick T.</creatorcontrib><creatorcontrib>Human Cell Atlas Lung Biological Network Consortium Members</creatorcontrib><creatorcontrib>Human Cell Atlas Lung Biological Network</creatorcontrib><title>Myocyte-Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2–Mediated Myocarditis</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Supplemental Digital Content is available in the text.</description><subject>Angiotensin-Converting Enzyme 2</subject><subject>Betacoronavirus - isolation &amp; purification</subject><subject>Betacoronavirus - pathogenicity</subject><subject>Cardiomyopathy, Dilated - genetics</subject><subject>Cardiomyopathy, Dilated - pathology</subject><subject>Cardiomyopathy, Hypertrophic - genetics</subject><subject>Cardiomyopathy, Hypertrophic - pathology</subject><subject>Cathepsin L - genetics</subject><subject>Cathepsin L - metabolism</subject><subject>Coronavirus Infections - complications</subject><subject>Coronavirus Infections - pathology</subject><subject>Coronavirus Infections - virology</subject><subject>Correspondence</subject><subject>COVID-19</subject><subject>Heart Ventricles - metabolism</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Myocarditis - diagnosis</subject><subject>Myocarditis - etiology</subject><subject>Myocardium - metabolism</subject><subject>Pandemics</subject><subject>Peptidyl-Dipeptidase A - chemistry</subject><subject>Peptidyl-Dipeptidase A - genetics</subject><subject>Peptidyl-Dipeptidase A - metabolism</subject><subject>Pneumonia, Viral - complications</subject><subject>Pneumonia, Viral - pathology</subject><subject>Pneumonia, Viral - virology</subject><subject>Protease Inhibitors - pharmacology</subject><subject>RNA-Seq</subject><subject>SARS-CoV-2</subject><subject>Serine Endopeptidases - genetics</subject><subject>Serine Endopeptidases - metabolism</subject><subject>Up-Regulation - drug effects</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpdkc1uEzEUhS0EoqHwCsgsWTjYnhn_sEAaTQuJlFKpadhajmM3hkk8siepsuMdeEOeBA8DFWVzrXvvOeda-gB4Q_CUEEbeNfObZrWob-fXn-tZPSUUT3HJJSFPwIRUtERlVcinYIIxlogXlJ6BFyl9zS0rePUcnBWUywpLMgHp6hTMqbdo2VnjnTdw1UV7d2h178MeBgfr5pJCv4eNjhsfjjqZvIzwwierk30P57uu9ea3PEEXIlzWN0vUhC-I_vz-48puvO7tBg53hoTep5fgmdNtsq_-vOdg9fHytpmhxfWneVMvkGGYEWQo58KsBWfWiEpgsiHaSsecxWvGiJSMa8aHKoRxa0GF06WUnJXCVZrR4hx8GHO7w3pnN8bu-6hb1UW_0_Gkgvbq8Wbvt-ouHBUvaSkkywFvx4Dtf7ZZvVDDDFMpaYHZkWStHLUmhpSidQ8GgtVATT2mpjI1NVLL3tf_fvTB-RdTFpSj4D60vY3pW3u4t1FtrW77rcpccYEJRxRTjAURGOVJzv0FEY-l9w</recordid><startdate>20200818</startdate><enddate>20200818</enddate><creator>Tucker, Nathan R.</creator><creator>Chaffin, Mark</creator><creator>Bedi, Kenneth C.</creator><creator>Papangeli, Irinna</creator><creator>Akkad, Amer-Denis</creator><creator>Arduini, Alessandro</creator><creator>Hayat, Sikander</creator><creator>Eraslan, Gökcen</creator><creator>Muus, Christoph</creator><creator>Bhattacharyya, Roby P.</creator><creator>Stegmann, Christian M.</creator><creator>Margulies, Kenneth B.</creator><creator>Ellinor, Patrick T.</creator><general>by the American College of Cardiology Foundation and the American Heart Association, Inc</general><general>American Heart Association</general><general>Lippincott Williams &amp; Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8093-4465</orcidid><orcidid>https://orcid.org/0000-0002-2067-0533</orcidid><orcidid>https://orcid.org/0000-0001-6955-5088</orcidid><orcidid>https://orcid.org/0000-0001-9632-6483</orcidid></search><sort><creationdate>20200818</creationdate><title>Myocyte-Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2–Mediated Myocarditis</title><author>Tucker, Nathan R. ; Chaffin, Mark ; Bedi, Kenneth C. ; Papangeli, Irinna ; Akkad, Amer-Denis ; Arduini, Alessandro ; Hayat, Sikander ; Eraslan, Gökcen ; Muus, Christoph ; Bhattacharyya, Roby P. ; Stegmann, Christian M. ; Margulies, Kenneth B. ; Ellinor, Patrick T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6061-c2778cb876ec85801d1ae9f6fe0b6619967a67967a88cfb828fa4997648f5a623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Angiotensin-Converting Enzyme 2</topic><topic>Betacoronavirus - isolation &amp; purification</topic><topic>Betacoronavirus - pathogenicity</topic><topic>Cardiomyopathy, Dilated - genetics</topic><topic>Cardiomyopathy, Dilated - pathology</topic><topic>Cardiomyopathy, Hypertrophic - genetics</topic><topic>Cardiomyopathy, Hypertrophic - pathology</topic><topic>Cathepsin L - genetics</topic><topic>Cathepsin L - metabolism</topic><topic>Coronavirus Infections - complications</topic><topic>Coronavirus Infections - pathology</topic><topic>Coronavirus Infections - virology</topic><topic>Correspondence</topic><topic>COVID-19</topic><topic>Heart Ventricles - metabolism</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Myocarditis - diagnosis</topic><topic>Myocarditis - etiology</topic><topic>Myocardium - metabolism</topic><topic>Pandemics</topic><topic>Peptidyl-Dipeptidase A - chemistry</topic><topic>Peptidyl-Dipeptidase A - genetics</topic><topic>Peptidyl-Dipeptidase A - metabolism</topic><topic>Pneumonia, Viral - complications</topic><topic>Pneumonia, Viral - pathology</topic><topic>Pneumonia, Viral - virology</topic><topic>Protease Inhibitors - pharmacology</topic><topic>RNA-Seq</topic><topic>SARS-CoV-2</topic><topic>Serine Endopeptidases - genetics</topic><topic>Serine Endopeptidases - metabolism</topic><topic>Up-Regulation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tucker, Nathan R.</creatorcontrib><creatorcontrib>Chaffin, Mark</creatorcontrib><creatorcontrib>Bedi, Kenneth C.</creatorcontrib><creatorcontrib>Papangeli, Irinna</creatorcontrib><creatorcontrib>Akkad, Amer-Denis</creatorcontrib><creatorcontrib>Arduini, Alessandro</creatorcontrib><creatorcontrib>Hayat, Sikander</creatorcontrib><creatorcontrib>Eraslan, Gökcen</creatorcontrib><creatorcontrib>Muus, Christoph</creatorcontrib><creatorcontrib>Bhattacharyya, Roby P.</creatorcontrib><creatorcontrib>Stegmann, Christian M.</creatorcontrib><creatorcontrib>Margulies, Kenneth B.</creatorcontrib><creatorcontrib>Ellinor, Patrick T.</creatorcontrib><creatorcontrib>Human Cell Atlas Lung Biological Network Consortium Members</creatorcontrib><creatorcontrib>Human Cell Atlas Lung Biological Network</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tucker, Nathan R.</au><au>Chaffin, Mark</au><au>Bedi, Kenneth C.</au><au>Papangeli, Irinna</au><au>Akkad, Amer-Denis</au><au>Arduini, Alessandro</au><au>Hayat, Sikander</au><au>Eraslan, Gökcen</au><au>Muus, Christoph</au><au>Bhattacharyya, Roby P.</au><au>Stegmann, Christian M.</au><au>Margulies, Kenneth B.</au><au>Ellinor, Patrick T.</au><aucorp>Human Cell Atlas Lung Biological Network Consortium Members</aucorp><aucorp>Human Cell Atlas Lung Biological Network</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myocyte-Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2–Mediated Myocarditis</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2020-08-18</date><risdate>2020</risdate><volume>142</volume><issue>7</issue><spage>708</spage><epage>710</epage><pages>708-710</pages><artnum>CIRCULATIONAHA.120.047911</artnum><issn>0009-7322</issn><eissn>1524-4539</eissn><abstract>Supplemental Digital Content is available in the text.</abstract><cop>United States</cop><pub>by the American College of Cardiology Foundation and the American Heart Association, Inc</pub><pmid>32795091</pmid><doi>10.1161/CIRCULATIONAHA.120.047911</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0002-8093-4465</orcidid><orcidid>https://orcid.org/0000-0002-2067-0533</orcidid><orcidid>https://orcid.org/0000-0001-6955-5088</orcidid><orcidid>https://orcid.org/0000-0001-9632-6483</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0009-7322
ispartof Circulation (New York, N.Y.), 2020-08, Vol.142 (7), p.708-710, Article CIRCULATIONAHA.120.047911
issn 0009-7322
1524-4539
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7424896
source EZB Electronic Journals Library
subjects Angiotensin-Converting Enzyme 2
Betacoronavirus - isolation & purification
Betacoronavirus - pathogenicity
Cardiomyopathy, Dilated - genetics
Cardiomyopathy, Dilated - pathology
Cardiomyopathy, Hypertrophic - genetics
Cardiomyopathy, Hypertrophic - pathology
Cathepsin L - genetics
Cathepsin L - metabolism
Coronavirus Infections - complications
Coronavirus Infections - pathology
Coronavirus Infections - virology
Correspondence
COVID-19
Heart Ventricles - metabolism
Humans
Life Sciences
Myocarditis - diagnosis
Myocarditis - etiology
Myocardium - metabolism
Pandemics
Peptidyl-Dipeptidase A - chemistry
Peptidyl-Dipeptidase A - genetics
Peptidyl-Dipeptidase A - metabolism
Pneumonia, Viral - complications
Pneumonia, Viral - pathology
Pneumonia, Viral - virology
Protease Inhibitors - pharmacology
RNA-Seq
SARS-CoV-2
Serine Endopeptidases - genetics
Serine Endopeptidases - metabolism
Up-Regulation - drug effects
title Myocyte-Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2–Mediated Myocarditis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T21%3A05%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Myocyte-Specific%20Upregulation%20of%20ACE2%20in%20Cardiovascular%20Disease:%20Implications%20for%20SARS-CoV-2%E2%80%93Mediated%20Myocarditis&rft.jtitle=Circulation%20(New%20York,%20N.Y.)&rft.au=Tucker,%20Nathan%20R.&rft.aucorp=Human%20Cell%20Atlas%20Lung%20Biological%20Network%20Consortium%20Members&rft.date=2020-08-18&rft.volume=142&rft.issue=7&rft.spage=708&rft.epage=710&rft.pages=708-710&rft.artnum=CIRCULATIONAHA.120.047911&rft.issn=0009-7322&rft.eissn=1524-4539&rft_id=info:doi/10.1161/CIRCULATIONAHA.120.047911&rft_dat=%3Cpubmed_hal_p%3E32795091%3C/pubmed_hal_p%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c6061-c2778cb876ec85801d1ae9f6fe0b6619967a67967a88cfb828fa4997648f5a623%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/32795091&rfr_iscdi=true