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Antiglycation and Antioxidant Properties of Ficus deltoidea Varieties
The present study aimed to evaluate the potential of standardized methanolic extracts from seven Ficus deltoidea varieties in inhibiting the formation of AGEs, protein oxidation, and their antioxidant effects. The antiglycation activity was analyzed based on the inhibition of AGEs, fructosamine, and...
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Published in: | Evidence-based complementary and alternative medicine 2020, Vol.2020 (2020), p.1-16 |
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creator | Nik Abd. Rahman, Nik Mohd Afizan Adam, Zainah Yahaya, Nurshieren Mohd Dom, Nur Sumirah Hamid, Muhajir |
description | The present study aimed to evaluate the potential of standardized methanolic extracts from seven Ficus deltoidea varieties in inhibiting the formation of AGEs, protein oxidation, and their antioxidant effects. The antiglycation activity was analyzed based on the inhibition of AGEs, fructosamine, and thiol groups level followed by the inhibition of protein carbonyl formation. The antioxidant activity (DPPH radical scavenging activity and reducing power assay) and total phenolic contents were evaluated. After 28 days of induction, all varieties of Ficus deltoidea extracts significantly restrained the formation of fluorescence AGEs by 4.55–5.14 fold. The extracts also reduced the fructosamine levels by 47.0–86.5%, increased the thiol group levels by 64.3–83.7%, and inhibited the formation of protein carbonyl by 1.36–1.76 fold. DPPH radical scavenging activity showed an IC50 value of 66.81–288.04 μg/ml and reducing power activity depicted at 0.02–0.24 μg/ml. The extent of phenolic compounds present in the extracts ranged from 70.90 to 299.78 mg·GAE/g. Apart from that, correlation studies between the activities were observed. This study revealed that seven varieties of Ficus deltoidea have the potential to inhibit AGEs formation and possess antioxidant activity that might be attributed to the presence of phenolic compounds. |
doi_str_mv | 10.1155/2020/6374632 |
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Rahman, Nik Mohd Afizan ; Adam, Zainah ; Yahaya, Nurshieren ; Mohd Dom, Nur Sumirah ; Hamid, Muhajir</creator><contributor>Lenon, George B. ; George B Lenon</contributor><creatorcontrib>Nik Abd. Rahman, Nik Mohd Afizan ; Adam, Zainah ; Yahaya, Nurshieren ; Mohd Dom, Nur Sumirah ; Hamid, Muhajir ; Lenon, George B. ; George B Lenon</creatorcontrib><description>The present study aimed to evaluate the potential of standardized methanolic extracts from seven Ficus deltoidea varieties in inhibiting the formation of AGEs, protein oxidation, and their antioxidant effects. The antiglycation activity was analyzed based on the inhibition of AGEs, fructosamine, and thiol groups level followed by the inhibition of protein carbonyl formation. The antioxidant activity (DPPH radical scavenging activity and reducing power assay) and total phenolic contents were evaluated. After 28 days of induction, all varieties of Ficus deltoidea extracts significantly restrained the formation of fluorescence AGEs by 4.55–5.14 fold. The extracts also reduced the fructosamine levels by 47.0–86.5%, increased the thiol group levels by 64.3–83.7%, and inhibited the formation of protein carbonyl by 1.36–1.76 fold. DPPH radical scavenging activity showed an IC50 value of 66.81–288.04 μg/ml and reducing power activity depicted at 0.02–0.24 μg/ml. The extent of phenolic compounds present in the extracts ranged from 70.90 to 299.78 mg·GAE/g. Apart from that, correlation studies between the activities were observed. This study revealed that seven varieties of Ficus deltoidea have the potential to inhibit AGEs formation and possess antioxidant activity that might be attributed to the presence of phenolic compounds.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2020/6374632</identifier><identifier>PMID: 32831872</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Analysis ; Antioxidants ; Carbonyl compounds ; Diabetes ; Ficus deltoidea ; Flavonoids ; Insulin resistance ; Oxidation ; Phenolic compounds ; Protein folding ; Proteins ; Thiols</subject><ispartof>Evidence-based complementary and alternative medicine, 2020, Vol.2020 (2020), p.1-16</ispartof><rights>Copyright © 2020 Nur Sumirah Mohd Dom et al.</rights><rights>COPYRIGHT 2020 John Wiley & Sons, Inc.</rights><rights>Copyright © 2020 Nur Sumirah Mohd Dom et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Nur Sumirah Mohd Dom et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-427efc7ab1ec0a465362b95e7049bf2dad4831334cf13d72ca0345721bf40ccf3</citedby><cites>FETCH-LOGICAL-c476t-427efc7ab1ec0a465362b95e7049bf2dad4831334cf13d72ca0345721bf40ccf3</cites><orcidid>0000-0003-4835-4687 ; 0000-0002-2475-7628 ; 0000-0001-8157-0635 ; 0000-0002-3140-832X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2434395751/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2434395751?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,4022,25752,27922,27923,27924,37011,37012,44589,74897</link.rule.ids></links><search><contributor>Lenon, George B.</contributor><contributor>George B Lenon</contributor><creatorcontrib>Nik Abd. Rahman, Nik Mohd Afizan</creatorcontrib><creatorcontrib>Adam, Zainah</creatorcontrib><creatorcontrib>Yahaya, Nurshieren</creatorcontrib><creatorcontrib>Mohd Dom, Nur Sumirah</creatorcontrib><creatorcontrib>Hamid, Muhajir</creatorcontrib><title>Antiglycation and Antioxidant Properties of Ficus deltoidea Varieties</title><title>Evidence-based complementary and alternative medicine</title><description>The present study aimed to evaluate the potential of standardized methanolic extracts from seven Ficus deltoidea varieties in inhibiting the formation of AGEs, protein oxidation, and their antioxidant effects. The antiglycation activity was analyzed based on the inhibition of AGEs, fructosamine, and thiol groups level followed by the inhibition of protein carbonyl formation. The antioxidant activity (DPPH radical scavenging activity and reducing power assay) and total phenolic contents were evaluated. After 28 days of induction, all varieties of Ficus deltoidea extracts significantly restrained the formation of fluorescence AGEs by 4.55–5.14 fold. The extracts also reduced the fructosamine levels by 47.0–86.5%, increased the thiol group levels by 64.3–83.7%, and inhibited the formation of protein carbonyl by 1.36–1.76 fold. DPPH radical scavenging activity showed an IC50 value of 66.81–288.04 μg/ml and reducing power activity depicted at 0.02–0.24 μg/ml. The extent of phenolic compounds present in the extracts ranged from 70.90 to 299.78 mg·GAE/g. Apart from that, correlation studies between the activities were observed. This study revealed that seven varieties of Ficus deltoidea have the potential to inhibit AGEs formation and possess antioxidant activity that might be attributed to the presence of phenolic compounds.</description><subject>Analysis</subject><subject>Antioxidants</subject><subject>Carbonyl compounds</subject><subject>Diabetes</subject><subject>Ficus deltoidea</subject><subject>Flavonoids</subject><subject>Insulin resistance</subject><subject>Oxidation</subject><subject>Phenolic compounds</subject><subject>Protein folding</subject><subject>Proteins</subject><subject>Thiols</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNqFkc2LFDEQxYMo7jp68ywNXgQdN59dnYswLLsqLOhBxVtIJ5XZLD3JmHSr-9_bzQy76MVTitSPV6_qEfKc0beMKXXGKadnrQDZCv6AnDKQbC151z28q-H7CXlS6w2lXAPAY3IieCdYB_yUXGzSGLfDrbNjzKmxyTfLT_4dvU1j87nkPZYxYm1yaC6jm2rjcRhz9Gibb7ZEXJpPyaNgh4rPju-KfL28-HL-YX316f3H883V2klox8UKBge2Z-iola0SLe-1QqBS94F76-XsSwjpAhMeuLNUSAWc9UFS54JYkXcH3f3U79A7TGOxg9mXuLPl1mQbzd-dFK_NNv80sFwE1Czw6ihQ8o8J62h2sTocBpswT9VwKdoOmJqPuSIv_0Fv8lTSvN5CSaEVKHZPbe2AJqaQ57luETWbVmitJXA9U28OlCu51oLhzjKjZknRLCmaY4oz_vqAX8fk7a_4P_rFgcaZwWDvaaZazaT4A3s4o7Y</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Nik Abd. 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Rahman, Nik Mohd Afizan</creatorcontrib><creatorcontrib>Adam, Zainah</creatorcontrib><creatorcontrib>Yahaya, Nurshieren</creatorcontrib><creatorcontrib>Mohd Dom, Nur Sumirah</creatorcontrib><creatorcontrib>Hamid, Muhajir</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nik Abd. Rahman, Nik Mohd Afizan</au><au>Adam, Zainah</au><au>Yahaya, Nurshieren</au><au>Mohd Dom, Nur Sumirah</au><au>Hamid, Muhajir</au><au>Lenon, George B.</au><au>George B Lenon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiglycation and Antioxidant Properties of Ficus deltoidea Varieties</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><date>2020</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>16</epage><pages>1-16</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>The present study aimed to evaluate the potential of standardized methanolic extracts from seven Ficus deltoidea varieties in inhibiting the formation of AGEs, protein oxidation, and their antioxidant effects. The antiglycation activity was analyzed based on the inhibition of AGEs, fructosamine, and thiol groups level followed by the inhibition of protein carbonyl formation. The antioxidant activity (DPPH radical scavenging activity and reducing power assay) and total phenolic contents were evaluated. After 28 days of induction, all varieties of Ficus deltoidea extracts significantly restrained the formation of fluorescence AGEs by 4.55–5.14 fold. The extracts also reduced the fructosamine levels by 47.0–86.5%, increased the thiol group levels by 64.3–83.7%, and inhibited the formation of protein carbonyl by 1.36–1.76 fold. DPPH radical scavenging activity showed an IC50 value of 66.81–288.04 μg/ml and reducing power activity depicted at 0.02–0.24 μg/ml. The extent of phenolic compounds present in the extracts ranged from 70.90 to 299.78 mg·GAE/g. Apart from that, correlation studies between the activities were observed. This study revealed that seven varieties of Ficus deltoidea have the potential to inhibit AGEs formation and possess antioxidant activity that might be attributed to the presence of phenolic compounds.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>32831872</pmid><doi>10.1155/2020/6374632</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0003-4835-4687</orcidid><orcidid>https://orcid.org/0000-0002-2475-7628</orcidid><orcidid>https://orcid.org/0000-0001-8157-0635</orcidid><orcidid>https://orcid.org/0000-0002-3140-832X</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Analysis Antioxidants Carbonyl compounds Diabetes Ficus deltoidea Flavonoids Insulin resistance Oxidation Phenolic compounds Protein folding Proteins Thiols |
title | Antiglycation and Antioxidant Properties of Ficus deltoidea Varieties |
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