Association of self-regulation with white matter correlates in boys with and without autism spectrum disorder

Previous studies demonstrated distinct neural correlates underpinning impaired self-regulation (dysregulation) between individuals with autism spectrum disorder (ASD) and typically developing controls (TDC). However, the impacts of dysregulation on white matter (WM) microstructural property in ASD a...

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Bibliographic Details
Published in:Scientific reports 2020-08, Vol.10 (1), p.13811-13811, Article 13811
Main Authors: Ni, Hsing-Chang, Lin, Hsiang-Yuan, Tseng, Wen-Yih Isaac, Gau, Susan Shur-Fen
Format: Article
Language:English
Subjects:
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Adolescent
Anisotropy
Attention
Autism
Autism Spectrum Disorder - pathology
Autism Spectrum Disorder - psychology
Child
Correlation analysis
Diagnosis
Emotions
Humanities and Social Sciences
Humans
Intelligence
Male
Memory
multidisciplinary
Multivariate analysis
Neuroimaging
Science
Science (multidisciplinary)
Self-Control
Sensorimotor system
Substantia alba
White Matter - pathology
White Matter - ultrastructure
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Summary:Previous studies demonstrated distinct neural correlates underpinning impaired self-regulation (dysregulation) between individuals with autism spectrum disorder (ASD) and typically developing controls (TDC). However, the impacts of dysregulation on white matter (WM) microstructural property in ASD and TDC remain unclear. Diffusion spectrum imaging was acquired in 59 ASD and 62 TDC boys. We investigated the relationship between participants’ dysregulation levels and microstructural property of 76 WM tracts in a multivariate analysis (canonical correlation analysis), across diagnostic groups. A single mode of brain-behavior co-variation was identified: participants were spread along a single axis linking diagnosis, dysregulation, diagnosis-by-dysregulation interaction, and intelligence to a specific WM property pattern. This mode corresponds to diagnosis-distinct correlates underpinning dysregulation, which showed higher generalized fractional anisotropy (GFA) associated with less dysregulation in ASD but greater dysregulation in TDC, in the tracts connecting limbic and emotion regulation systems. Moreover, higher GFA of the tracts implicated in memory, attention, sensorimotor processing, and perception associated with less dysregulation in TDC but worse dysregulation in ASD. No shared WM correlates of dysregulation between ASD and TDC were identified. Corresponding to previous studies, we demonstrated that ASD and TDC have broad distinct white matter microstructural property underpinning self-regulation.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-70836-y