Emerging Role of Extracellular Vesicles in Embryo-Maternal Communication throughout Implantation Processes

In ruminants, the establishment of proper conceptus-endometrial communication is essential for conceptus implantation and subsequent successful placentation. Accumulated evidence supports the idea that extracellular vesicles (EVs) present in uterine lumen are involved in conceptus-endometrial intera...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-08, Vol.21 (15), p.5523
Main Authors: Nakamura, Keigo, Kusama, Kazuya, Suda, Yoshihito, Fujiwara, Hiroshi, Hori, Masatoshi, Imakawa, Kazuhiko
Format: Article
Language:English
Subjects:
Animals
Biological effects
Biosynthesis
Cattle
Cell proliferation
Cloning
Communication
Deoxyribonucleic acid
DNA
Embryo Implantation
Embryo, Mammalian - embryology
Embryo, Mammalian - metabolism
Embryos
Endometrium
Endometrium - metabolism
Extracellular vesicles
Extracellular Vesicles - metabolism
Female
Gene expression
Implantation
Interferon
Lipids
Metabolites
Physiology
Plasma
Pregnancy
Progesterone
Prostaglandins
Proteins
Review
Ruminants - embryology
Ruminants - metabolism
Sheep
Signal Transduction
Trophectoderm
Ungulates
Uterus
Uterus - metabolism
Vesicles
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Summary:In ruminants, the establishment of proper conceptus-endometrial communication is essential for conceptus implantation and subsequent successful placentation. Accumulated evidence supports the idea that extracellular vesicles (EVs) present in uterine lumen are involved in conceptus-endometrial interactions during the preimplantation period. EVs make up a new field of intercellular communicators, which transport a variety of bioactive molecules, including soluble and membrane-bound proteins, lipids, DNA, and RNAs. EVs thus regulate gene expression and elicit biological effects including increased cell proliferation, migration, and adhesion in recipient cells. Uterine EVs are interactive and coordinate with ovarian progesterone (P4), trophectoderm-derived interferon tau (IFNT) and/or prostaglandins (PGs) in the physiological or pathological microenvironment. In this review, we will focus on intrauterine EVs in embryo-maternal interactions during the early stage of pregnancy, especially the implantation period in ruminant ungulates.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21155523