Urinary Biomarkers of Exposure to Volatile Organic Compounds from the Population Assessment of Tobacco and Health Study Wave 1 (2013-2014)

Volatile organic compounds (VOCs) are ubiquitous in the environment. In the United States (U.S.), tobacco smoke is the major non-occupational source of exposure to many harmful VOCs. Exposure to VOCs can be assessed by measuring their urinary metabolites (VOCMs). The Population Assessment of Tobacco...

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Bibliographic Details
Published in:International journal of environmental research and public health 2020-07, Vol.17 (15), p.5408
Main Authors: De Jesús, Víctor R, Bhandari, Deepak, Zhang, Luyu, Reese, Christopher, Capella, Kimberly, Tevis, Denise, Zhu, Wanzhe, Del Valle-Pinero, Arseima Y, Lagaud, Guy, Chang, Joanne T, van Bemmel, Dana, Kimmel, Heather L, Sharma, Eva, Goniewicz, Maciej L, Hyland, Andrew, Blount, Benjamin C
Format: Article
Language:English
Subjects:
Acrolein
Acrylonitrile
Adolescent
Adult
Adults
Biomarkers
Biomarkers - urine
Butadiene
Cancer
Correlation analysis
Creatinine
Electronic cigarettes
Electronic Nicotine Delivery Systems
Exposure
Flammability
Humans
Hypothesis testing
Isoprene
Longitudinal Studies
Male
Metabolites
Occupational exposure
Organic compounds
Population
Regression analysis
Smoking
Studies
Tobacco
Tobacco Products
United States - epidemiology
Urine
User groups
VOCs
Volatile Organic Compounds
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Summary:Volatile organic compounds (VOCs) are ubiquitous in the environment. In the United States (U.S.), tobacco smoke is the major non-occupational source of exposure to many harmful VOCs. Exposure to VOCs can be assessed by measuring their urinary metabolites (VOCMs). The Population Assessment of Tobacco and Health (PATH) Study is a U.S. national longitudinal study of tobacco use in the adult and youth civilian non-institutionalized population. We measured 20 VOCMs in urine specimens from a subsample of adults in Wave 1 (W1) (2013-2014) to characterize VOC exposures among tobacco product users and non-users. We calculated weighted geometric means (GMs) and percentiles of each VOCM for exclusive combustible product users (smokers), exclusive electronic cigarette (e-cigarette) users, exclusive smokeless product users, and tobacco product never users. We produced linear regression models for six VOCMs with sex, age, race, and tobacco user group as predictor variables. Creatinine-ratioed levels of VOCMs from exposure to acrolein, crotonaldehyde, isoprene, acrylonitrile, and 1,3-butadiene were significantly higher in smokers than in never users. Small differences of VOCM levels among exclusive e-cigarette users and smokeless users were observed when compared to never users. Smokers showed higher VOCM concentrations than e-cigarette, smokeless, and never users. Urinary VOC metabolites are useful biomarkers of exposure to harmful VOCs.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph17155408