PTEN Function at the Interface between Cancer and Tumor Microenvironment: Implications for Response to Immunotherapy

Mounting preclinical and clinical evidence indicates that rewiring the host immune system in favor of an antitumor microenvironment achieves remarkable clinical efficacy in the treatment of many hematological and solid cancer patients. Nevertheless, despite the promising development of many new and...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-07, Vol.21 (15), p.5337
Main Authors: Conciatori, Fabiana, Bazzichetto, Chiara, Falcone, Italia, Ciuffreda, Ludovica, Ferretti, Gianluigi, Vari, Sabrina, Ferraresi, Virginia, Cognetti, Francesco, Milella, Michele
Format: Article
Language:English
Subjects:
Antigens
Cancer
Cancer immunotherapy
Cell cycle
Chromosome 10
Chromosomes
Cytokines
Cytotoxicity
Homology
Humans
Immune system
Immunoglobulins
Immunology
Immunotherapy
Kinases
Ligands
Lymphocytes
Melanoma
Neoplasms - immunology
Neoplasms - pathology
Neoplasms - therapy
Phosphatase
Proteins
PTEN Phosphohydrolase - immunology
PTEN protein
Review
Rewiring
Sensitivity
Stromal cells
T cell receptors
Tensin
Tumor Microenvironment - immunology
Tumor suppressor genes
Vaccines
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Summary:Mounting preclinical and clinical evidence indicates that rewiring the host immune system in favor of an antitumor microenvironment achieves remarkable clinical efficacy in the treatment of many hematological and solid cancer patients. Nevertheless, despite the promising development of many new and interesting therapeutic strategies, many of these still fail from a clinical point of view, probably due to the lack of prognostic and predictive biomarkers. In that respect, several data shed new light on the role of the tumor suppressor phosphatase and tensin homolog on chromosome 10 (PTEN) in affecting the composition and function of the tumor microenvironment (TME) as well as resistance/sensitivity to immunotherapy. In this review, we summarize current knowledge on PTEN functions in different TME compartments (immune and stromal cells) and how they can modulate sensitivity/resistance to different immunological manipulations and ultimately influence clinical response to cancer immunotherapy.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21155337