Emerging translation strategies during virus–host interaction

Translation control is crucial during virus–host interaction. On one hand, viruses completely rely on the protein synthesis machinery of host cells to propagate and have evolved various mechanisms to redirect the host's ribosomes toward their viral mRNAs. On the other hand, the host rewires its...

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Bibliographic Details
Published in:Wiley Interdisciplinary Reviews: RNA 2021-01, Vol.12 (1), p.e1619-n/a
Main Authors: Hoang, Huy‐Dung, Neault, Serge, Pelin, Adrian, Alain, Tommy
Format: Article
Language:English
Subjects:
Advanced Review
Advanced Reviews
Infections
mRNA
N6‐methyladenosine
Protein biosynthesis
Protein synthesis
Proteins
Ribosomes
Translation
Translation Mechanisms
Translation Regulation
tRNA fragment
tRNA pool
virus
Viruses
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Summary:Translation control is crucial during virus–host interaction. On one hand, viruses completely rely on the protein synthesis machinery of host cells to propagate and have evolved various mechanisms to redirect the host's ribosomes toward their viral mRNAs. On the other hand, the host rewires its translation program in an attempt to contain and suppress the virus early on during infection; the antiviral program includes specific control on protein synthesis to translate several antiviral mRNAs involved in quenching the infection. As the infection progresses, host translation is in turn inhibited in order to limit viral propagation. We have learnt of very diverse strategies that both parties utilize to gain or retain control over the protein synthesis machinery. Yet novel strategies continue to be discovered, attesting for the importance of mRNA translation in virus–host interaction. This review focuses on recently described translation strategies employed by both hosts and viruses. These discoveries provide additional pieces in the understanding of the complex virus–host translation landscape. This article is categorized under: Translation > Translation Mechanisms Translation > Translation Regulation Translation control of mammalian cells during viral infection can be impacted by tRNA fragments, N6‐methyladenosine (m6A), or modified tRNA pools.
ISSN:1757-7004
1757-7012
DOI:10.1002/wrna.1619