Roles of long non-coding RNAs in the hallmarks of glioma (Review)

Glioma is one of the most common types of tumor of the central nervous system. Due to the aggressiveness and invasiveness of high-level gliomas, the survival time of patients with these tumors is short, at ~15 months, even after combined treatment with surgery, radiotherapy and/or chemotherapy. Rece...

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Bibliographic Details
Published in:Oncology letters 2020-10, Vol.20 (4), p.1-83
Main Authors: Xue, Bing-Zhou, Xiang, Wei, Zhang, Qing, Wang, Yi-Hao, Wang, Hao-Fei, Yi, Dong-Ye, Xiong, Nan-Xiang, Jiang, Xiao-Bing, Zhao, Hong-Yang, Fu, Peng
Format: Article
Language:English
Subjects:
Angiogenesis
Apoptosis
Cell cycle
Cell growth
Chemotherapy
Cyclin-dependent kinases
Development and progression
Genes
Genomes
Glioma
Gliomas
Growth factors
Kinases
Medical prognosis
Oncology
Prostate cancer
Proteins
Review
RNA
Roles
Transcription factors
Tumors
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Summary:Glioma is one of the most common types of tumor of the central nervous system. Due to the aggressiveness and invasiveness of high-level gliomas, the survival time of patients with these tumors is short, at ~15 months, even after combined treatment with surgery, radiotherapy and/or chemotherapy. Recently, a number of studies have demonstrated that long non-coding RNA (IncRNAs) serve crucial roles in the multistep development of human gliomas. Gliomas acquire numerous biological abilities during multistep development that collectively constitute the hallmarks of glioma. Thus, in this review, the roles of IncRNAs associated with glioma hallmarks and the current and future prospects for their development are summarized. Contents 1. Introduction 2. Roles of IncRNAs in the hallmarks of glioma 3. Roles of IncRNAs in glioma subpopulations 4. Conclusions and future perspectives
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2020.11944