Relationships between the Nicotine Metabolite Ratio and a Panel of Exposure and Effect Biomarkers: Findings from Two Studies of U.S. Commercial Cigarette Smokers

We examined the nicotine metabolite ratio's (NMR) relationship with smoking intensity, nicotine dependence, and a broad array of biomarkers of exposure and biological effect in commercial cigarette smokers. Secondary analysis was conducted on two cross-sectional samples of adult, daily smokers...

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Bibliographic Details
Published in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2020-04, Vol.29 (4), p.871-879
Main Authors: Carroll, Dana M, Murphy, Sharon E, Benowitz, Neal L, Strasser, Andrew A, Kotlyar, Michael, Hecht, Stephen S, Carmella, Steve G, McClernon, Francis J, Pacek, Lauren R, Dermody, Sarah S, Vandrey, Ryan G, Donny, Eric C, Hatsukami, Dorothy K
Format: Article
Language:English
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Summary:We examined the nicotine metabolite ratio's (NMR) relationship with smoking intensity, nicotine dependence, and a broad array of biomarkers of exposure and biological effect in commercial cigarette smokers. Secondary analysis was conducted on two cross-sectional samples of adult, daily smokers from Wave 1 (2013-2014) of the Population Assessment of Tobacco Use and Health (PATH) Study and baseline data from a 2014-2017 randomized clinical trial. Data were restricted to participants of non-Hispanic, white race. The lowest quartile of NMR (
ISSN:1055-9965
1538-7755
DOI:10.1158/1055-9965.EPI-19-0644