Adjuvant chemotherapy-associated lipid changes in breast cancer patients: A real-word retrospective analysis

Adjuvant chemotherapy may cause alterations in serum lipids in postoperative breast cancer (BC) patients, but the specific alterations caused by different chemotherapy regimens remain unclear. The aim of this study was to investigate the status of serum lipids pre- and post-chemotherapy and to compa...

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Bibliographic Details
Published in:Medicine (Baltimore) 2020-08, Vol.99 (33), p.e21498-e21498
Main Authors: He, Tao, Wang, Chengshi, Tan, Qiuwen, Wang, Zhu, Li, Jiayuan, Chen, Tao, Cui, Kaijun, Wu, Yunhao, Sun, Jiani, Zheng, Danxi, Lv, Qing, Chen, Jie
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Breast Neoplasms - drug therapy
Breast Neoplasms - surgery
Chemotherapy, Adjuvant
Female
Humans
Lipids - blood
Middle Aged
Observational Study
Retrospective Studies
Risk Factors
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Summary:Adjuvant chemotherapy may cause alterations in serum lipids in postoperative breast cancer (BC) patients, but the specific alterations caused by different chemotherapy regimens remain unclear. The aim of this study was to investigate the status of serum lipids pre- and post-chemotherapy and to compare the side effects of different chemotherapy regimens on serum lipid.We retrospectively analysed the lipid profiles of 1934 consecutive postoperative BC patients who received one of the following chemotherapy regimens:The levels of triglycerides (TG), total cholesterols (TC), and low-density lipoprotein (LDL-C) were significantly elevated in patients who received chemotherapy regimens above (P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000021498