Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: A case report

Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is a rare neoplasm characterized by morphological analogy to papillary thyroid carcinoma and the abnormal expression of thyroid transcription factor-1 (TTF-1). We herein report a rare case of TL-LGNPPA with a review of its cl...

Full description

Saved in:
Bibliographic Details
Published in:Medicine (Baltimore) 2020-08, Vol.99 (33), p.e21599-e21599
Main Authors: Maocai, Li, Fuxing, Liu, Lianqing, Li, Lili, Gong, WenChao, Duan, ShouZhou, Liu
Format: Article
Language:English
Subjects:
Adenocarcinoma, Papillary - pathology
Adenocarcinoma, Papillary - surgery
Clinical Case Report
Diagnosis, Differential
Female
Humans
Middle Aged
Nasopharyngeal Carcinoma - pathology
Nasopharyngeal Carcinoma - surgery
Neoplasm Staging
Thyroid Neoplasms - pathology
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is a rare neoplasm characterized by morphological analogy to papillary thyroid carcinoma and the abnormal expression of thyroid transcription factor-1 (TTF-1). We herein report a rare case of TL-LGNPPA with a review of its clinical and morphological characteristics and the treatment provided. The patient was a 50-year-old Chinese woman with the complaint of a three-year history of phlegm with blood with pharyngeal discomfort. There were no remarkable physical findings, and the laboratory tests were normal. Laryngoscopy and nasal computed tomography identified a mass at the posterior end of the nasal septum. Histologically, the tumor exhibited an oval papillary growth. Immunohistochemically, the neoplastic cells were positive for TTF-1, vimentin, cytokeratin 7, and cytokeratin 19. Pathological examination indicated a thyroid-like low-grade nasopharyngeal papillary adenocarcinoma. The neoplasm was completely resected without any complication. The patient had neither local recurrence nor distant metastasis 1 year after the removal of the tumor. Although TL-LGNPPA is a malignant tumor, complete surgical resection is an effective treatment.
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000021599