Association between tumor necrosis factor α and uterine fibroids: A protocol of systematic review

This study will explore the association between tumor necrosis factor α (TNF-α) and uterine fibroids (UFs). We will retrieve electronic databases in Cochrane Library, PUBMED, EMBASE, Web of Science, WANGFANG, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure from in...

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Bibliographic Details
Published in:Medicine (Baltimore) 2020-08, Vol.99 (33), p.e21667-e21667
Main Authors: Gao, Li-nan, Ge, Lian-gang, Zhu, Ming-zhe, Yao, Xin-xin
Format: Article
Language:English
Subjects:
Biomarkers, Tumor
Case-Control Studies
Female
Humans
Leiomyoma - metabolism
Study Protocol Systematic Review
Systematic Reviews as Topic
Tumor Necrosis Factor-alpha - metabolism
Uterine Neoplasms - metabolism
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Summary:This study will explore the association between tumor necrosis factor α (TNF-α) and uterine fibroids (UFs). We will retrieve electronic databases in Cochrane Library, PUBMED, EMBASE, Web of Science, WANGFANG, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure from inception to the present. All potential case-controlled studies investigating the association between TNF-α and UFs will be included in this study. Two researchers will independently select literature, appraise study quality, and extract outcome data. We will utilize a fixed-effects model or a random-effects model to synthesize outcome data. All data analysis will be performed by RevMan 5.3 software. The present study will supply high-quality synthesis and/or descriptive analysis of the recent evidence to explore the association between TNF-α and UFs. This study will exert evidence to determine whether or not TNF-α is associated with UFs. INPLASY202070010.
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000021667