Impact of the Film Array Meningitis/Encephalitis panel in adults with meningitis and encephalitis in Colombia

The Biofire® Film Array Meningitis Encephalitis (FAME) panel can rapidly diagnose common aetiologies but its impact in Colombia is unknown. A retrospective study of adults with CNS infections in one tertiary hospital in Colombia. The cohort was divided into two time periods: before and after the imp...

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Bibliographic Details
Published in:Epidemiology and infection 2020-01, Vol.148, p.e173-e173, Article e173
Main Authors: Díaz, Karen Melissa Ordóñez, Piedrahíta, John Alexander Alzate, Suárez Brochero, Oscar Felipe, Granada, Daniel Orozco, Barón, Laura Marcela, Bonilla, Isabella Cortés, Hasbun, Rodrigo
Format: Article
Language:English
Subjects:
Adults
Antibiotics
Antigens
Antimicrobial agents
Arrays
Blood
Cytomegalovirus
Diagnostic tests
Encephalitis
Etiology
Fungi
Herpes viruses
HIV
Hospitals
Human immunodeficiency virus
Infections
Infectious diseases
Laboratories
Magnetic resonance imaging
Meningitis
Mortality
Original Paper
Streptococcus infections
Studies
Therapy
Viruses
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Summary:The Biofire® Film Array Meningitis Encephalitis (FAME) panel can rapidly diagnose common aetiologies but its impact in Colombia is unknown. A retrospective study of adults with CNS infections in one tertiary hospital in Colombia. The cohort was divided into two time periods: before and after the implementation of the Biofire® FAME panel in May 2016. A total of 98 patients were enrolled, 52 and 46 were enrolled in the Standard of Care (SOC) group and in the FAME group, respectively. The most common comorbidity was human immunodeficiency virus infection (47.4%). The median time to a change in therapy was significantly shorter in the FAME group than in the SOC group (3 vs. 137.3 h, P < 0.001). This difference was driven by the timing to appropriate therapy (2.1 vs. 195 h, P < 0.001) by identifying viral aetiologies. Overall outcomes and length of stay were no different between both groups (P > 0.2). The FAME panel detected six aetiologies that had negative cultures but missed identifying one patient with Cryptococcus neoformans. The introduction of the Biofire FAME panel in Colombia has facilitated the identification of viral pathogens and has significantly reduced the time to the adjustment of empirical antimicrobial therapy.
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268820001648