Potential clinical application of an automated fluorescent microbial cell counter in the detection of urinary tract infection

Background Urinary tract infections (UTI) account for millions of office visits and approximately 400 000 hospital admissions every year in the United States; as a result, the cost burden of UTI in the USA is estimated at approximately $2.8 billion. There is a great deal of interest in finding newer...

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Bibliographic Details
Published in:Journal of clinical laboratory analysis 2020-08, Vol.34 (8), p.e23334-n/a
Main Authors: Phillips, Laila E., Verma, Sandeep, Surapaneni, Balarama K., Dutta, Sudhir K.
Format: Article
Language:English
Subjects:
Automation
Bacteria
Bacterial infections
Bacteriuria
Blood
Cell culture
cellular quantification
clinical diagnostics
E coli
Escherichia coli
Laboratories
Methods
microbiology
Microorganisms
Urinalysis
Urinary tract
urinary tract infection
Urinary tract infections
Urine
Urogenital system
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Summary:Background Urinary tract infections (UTI) account for millions of office visits and approximately 400 000 hospital admissions every year in the United States; as a result, the cost burden of UTI in the USA is estimated at approximately $2.8 billion. There is a great deal of interest in finding newer, faster, and more reliable methods for diagnosing UTI as compared to the standard urine culture. Methods An automated fluorescent microbial cell counter was used to compare urine samples found to be positive for Escherichia coli UTI via cell culturing (n = 11) with UTI‐negative samples (n = 10). Results Patients with a positive urine culture had significantly higher cell count results using the microbial cell counter (1.01 × 108 cells/mL) as compared to the negative samples (2.35 × 106 cells/mL; P = .0022). Conclusions These observations suggest that automated microbial cell counters may serve as a rapid, objective method for the detection of bacteriuria in urine samples submitted for evaluation of suspected UTI.
ISSN:0887-8013
1098-2825
DOI:10.1002/jcla.23334