Prognostic factors for neurological outcomes in Korean targeted temperature management recipients with return of spontaneous circulation after out-of-hospital cardiac arrests: A nationwide observational study

• Published in: Medicine (Baltimore) 2020-04, Vol.99 (15), p.e19581-e19581
• Main Authors: Kim, Jae Guk, Shin, Hyungoo, Choi, Hyun Young, Kim, Wonhee, Kim, Jihoon, Moon, Shinje, Kim, Bongyoung, Ahn, Chiwon, Lee, Juncheol
• Format: Article
• Language: English
• Subjects: Adult; Aged; Female; Humans; Hypothermia, Induced; Male; Middle Aged; Nervous System Diseases - diagnosis; Nervous System Diseases - etiology; Nervous System Diseases - prevention & control; Observational Study; Out-of-Hospital Cardiac Arrest - complications; Out-of-Hospital Cardiac Arrest - diagnosis; Out-of-Hospital Cardiac Arrest - therapy; Prognosis; Retrospective Studies
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000019581

Targeted temperature management (TTM) is recommended for comatose patients after out-of-hospital cardiac arrests (OHCAs). Even after successful TTM, several factors could influence the neuroprotective effect of TTM. The aim of this study is to identify prognostic factors associated with good neurological outcomes in TTM recipients.This study used nationwide data during 2012 to 2016 to investigate prognostic factors associated with good neurological outcomes in patients who received TTM after the return of spontaneous circulation (ROSC). Multivariate logistic regression analysis was conducted to analyse the factors that may affect the neurological outcomes in the TTM recipients.The study included 1578 eligible patients, comprising 767 with good and 811 with poor neurological outcomes. Multivariable analyses showed that OHCA in public places (OR, 1.599; 95% CI, 1.100-2.323, P = .014), initial shockable rhythms (OR, 1.721; 95% CI, 1.191-2.486, P = .004), pre-hospital ROSCs (OR, 6.748; 95% CI, 4.703-9.682, P