Paths of FGFR-driven tumorigenesis

Fibroblast growth factor receptors (FGFRs) comprise a subfamily of receptor tyrosine kinases (RTKs) that are master regulators of a broad spectrum of cellular and developmental processes, including apoptosis, proliferation, migration, and angiogenesis. Due to their broad impact, FGFRs and other RTKs...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2009-02, Vol.8 (4), p.580-588
Main Authors: Acevedo, Victor D., Ittmann, Michael, Spencer, David M.
Format: Article
Language:English
Subjects:
Animals
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cell Communication
Cycle
Disease Progression
Epithelial Cells - physiology
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Landes
Male
Neovascularization, Pathologic
Organogenesis
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
Prostatic Neoplasms - physiopathology
Protein Isoforms - genetics
Protein Isoforms - metabolism
Protein-Tyrosine Kinases - metabolism
Proteins
Receptors, Androgen - metabolism
Receptors, Fibroblast Growth Factor - genetics
Receptors, Fibroblast Growth Factor - metabolism
Signal Transduction - physiology
Stromal Cells - physiology
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Summary:Fibroblast growth factor receptors (FGFRs) comprise a subfamily of receptor tyrosine kinases (RTKs) that are master regulators of a broad spectrum of cellular and developmental processes, including apoptosis, proliferation, migration, and angiogenesis. Due to their broad impact, FGFRs and other RTKs are highly regulated and normally only basally active. Deregulation of FGFR signaling by activating mutations or ligand/receptor overexpression could allow these receptors to become constitutively active, leading to cancer development, including both hematopoietic and solid tumors, such as breast, bladder, and prostate carcinomas.  In this review, we focus on potential modes of FGFR-mediated tumorigenesis, in particular, the role of FGFR1 during prostate cancer progression.
ISSN:1538-4101
1551-4005
DOI:10.4161/cc.8.4.7657