Zona pellucida shear modulus, a possible novel non-invasive method to assist in embryo selection during in-vitro fertilization treatment

The present study investigated the association between oocyte zona pellucida shear modulus (ZPSM) and implantation rate (IR). Ninety-three oocytes collected from 38 in-vitro fertilization patients who underwent intracytoplasmic sperm injection were included in this case–control study. The ZP was mod...

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Bibliographic Details
Published in:Scientific reports 2020-08, Vol.10 (1), p.14066-14066, Article 14066
Main Authors: Priel, Elad, Priel, Tsvia, Szaingurten-Solodkin, Irit, Wainstock, Tamar, Perets, Yuval, Zeadna, Atif, Harlev, Avi, Lunenfeld, Eitan, Levitas, Eliahu, Har-Vardi, Iris
Format: Article
Language:English
Subjects:
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639/705
692/308
Adult
Case-Control Studies
Computer applications
Embryo Implantation
Embryos
Female
Humanities and Social Sciences
Humans
In vitro fertilization
Maternal Age
multidisciplinary
Oocytes
Oocytes - physiology
Pregnancy
Pregnancy Rate
Regression analysis
Science
Science (multidisciplinary)
Shear Strength
Single-Blind Method
Sperm Injections, Intracytoplasmic - methods
Zona pellucida
Zona Pellucida - physiology
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Summary:The present study investigated the association between oocyte zona pellucida shear modulus (ZPSM) and implantation rate (IR). Ninety-three oocytes collected from 38 in-vitro fertilization patients who underwent intracytoplasmic sperm injection were included in this case–control study. The ZP was modeled as an isotropic compressible hyperelastic material with parameter C 10 , which represents the ZPSM. Computational methodology was used to calculate the mechanical parameters that govern ZP deformation. Fifty-one developed embryos were transferred and divided into two groups—implanted and not implanted. Multivariate logistic regression analysis was performed to identify the association between ZPSM and IR while controlling for confounders. Maternal age and number of embryos per transfer were significantly associated with implantation. The IR of embryos characterized by C 10 values in the range of 0.20–0.40 kPa was 66.75%, while outside this range it was 6.70%. This range was significantly associated with implantation ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-70739-y