Catatonic features in children and adolescents with N-methyl-d-aspartate receptor antibody encephalitis

Catatonia is a psychomotor dysregulation syndrome of diverse aetiology, increasingly recognised as a prominent feature of N-methyl-d-aspartate receptor antibody encephalitis (NMDARE) in adults. No study to date has systematically assessed the prevalence and symptomatology of catatonia in children wi...

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Bibliographic Details
Published in:BJPsych open 2020-07, Vol.6 (4), p.e71-e71, Article e71
Main Authors: Eyre, Michael, Kaushik, Anya, Barrett, Elizabeth, King, Mary D., Pollak, Thomas, Dale, Russell C., Byrne, Susan, Lim, Ming
Format: Article
Language:English
Subjects:
Antibodies
Autoimmune diseases
Catatonia
Encephalitis
Immunotherapy
Magnetic resonance imaging
Patients
Psychiatrists
Short Report
Teenagers
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Summary:Catatonia is a psychomotor dysregulation syndrome of diverse aetiology, increasingly recognised as a prominent feature of N-methyl-d-aspartate receptor antibody encephalitis (NMDARE) in adults. No study to date has systematically assessed the prevalence and symptomatology of catatonia in children with NMDARE. We analysed 57 paediatric patients with NMDARE from the literature using the Bush-Francis Catatonia Rating Scale. Catatonia was common (occurring in 86% of patients), manifesting as complex clusters of positive and negative features within individual patients. It was both underrecognised and undertreated. Immunotherapy was the only effective intervention, highlighting the importance of prompt recognition and treatment of the underlying cause of catatonia.
ISSN:2056-4724
2056-4724
DOI:10.1192/bjo.2020.55