Protein acetylation and deacetylation: An important regulatory modification in gene transcription (Review)

Cells primarily rely on proteins to perform the majority of their physiological functions, and the function of proteins is regulated by post-translational modifications (PTMs). The acetylation of proteins is a dynamic and highly specific PTM, which has an important influence on the functions of prot...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2020-10, Vol.20 (4), p.2923-2940
Main Authors: Xia, Can, Tao, Yu, Li, Mingshan, Che, Tuanjie, Qu, Jing
Format: Article
Language:English
Subjects:
Aging
Cell cycle
Cellular signal transduction
Cytoplasm
Deoxyribonucleic acid
DNA
DNA methylation
Enzymes
Genes
Genetic aspects
Histones
Innovations
Kinases
Lysine
Mass spectrometry
Physiology
Proteins
Regulation
Review
Senescence
Signal transduction
Tetracyclines
Transcription (Genetics)
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Summary:Cells primarily rely on proteins to perform the majority of their physiological functions, and the function of proteins is regulated by post-translational modifications (PTMs). The acetylation of proteins is a dynamic and highly specific PTM, which has an important influence on the functions of proteins, such as gene transcription and signal transduction. The acetylation of proteins is primarily dependent on lysine acetyltransferases and lysine deacetylases. In recent years, due to the widespread use of mass spectrometry and the emergence of new technologies, such as protein chips, studies on protein acetylation have been further developed. Compared with histone acetylation, acetylation of non-histone proteins has gradually become the focus of research due to its important regulatory mechanisms and wide range of applications. The discovery of specific protein acetylation sites using bioinformatic tools can greatly aid the understanding of the underlying mechanisms of protein acetylation involved in related physiological and pathological processes.
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2020.9073