J-shaped association between fasting blood glucose levels and COVID-19 severity in patients without diabetes

•FBG is J-shaped associated with COVID-19 severity in non-diabetic patients.•Optimal Fasting glycemic target for COVID-19 patients is 4.74–5.78 mmol/L.•Both low and high FBG levels are increase COVID-19 severe/critical rate. Coronavirus disease 2019 (COVID-19) has become a recognized worldwide pande...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2020-10, Vol.168, p.108381-108381, Article 108381
Main Authors: Zhu, Bing, Jin, Shengwei, Wu, Lianpeng, Hu, Chenchan, Wang, Zhen, Bu, Le, Sun, Hang, Wang, Xingchun, Qu, Shen, Chen, Dong
Format: Article
Language:English
Subjects:
Adult
Aged
Betacoronavirus - physiology
Blood Glucose - analysis
China - epidemiology
Coronavirus disease 2019 (COVID-19)
Coronavirus Infections - blood
Coronavirus Infections - diagnosis
Coronavirus Infections - mortality
Coronavirus Infections - pathology
COVID-19
Disease Progression
Fasting - blood
Fasting blood glucose
Female
Glycemic target
Humans
Hyperglycemia
Hyperglycemia - blood
Hyperglycemia - complications
Hyperglycemia - diagnosis
Hypoglycemia
Male
Middle Aged
Pandemics
Pneumonia, Viral - blood
Pneumonia, Viral - diagnosis
Pneumonia, Viral - mortality
Pneumonia, Viral - pathology
Predictive Value of Tests
Prognosis
Retrospective Studies
SARS-CoV-2
Severity of Illness Index
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Summary:•FBG is J-shaped associated with COVID-19 severity in non-diabetic patients.•Optimal Fasting glycemic target for COVID-19 patients is 4.74–5.78 mmol/L.•Both low and high FBG levels are increase COVID-19 severe/critical rate. Coronavirus disease 2019 (COVID-19) has become a recognized worldwide pandemic. Researchers now know that mortality from COVID-19 can be reduced through early prevention measures. This retrospective, multi-centered study of 293 COVID-19 patients without diabetes explores the association between fasting blood glucose (FBG) levels and the risk of COVID-19 disease progression, with the goal of providing clinical evidence for glycemic targets in patients. The multivariate stepwise binary logistic regression analysis was used to test the dose–response effects of FBG levels on the risk of severe and critical condition in COVID-19 patients. FBG levels were plotted in quintiles with set at
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2020.108381