Intensive care unit acquired weakness: A protocol for an overview of systematic reviews and meta-analysis

• Published in: Medicine (Baltimore) 2020-08, Vol.99 (34), p.e21926-e21926
• Main Authors: Li, Zheng, Cai, Yitong, Zhang, Qian, Zhang, Peng, Sun, Ruixiang, Jiang, Haijiao, Wan, JingJing, Wu, Fang, Wang, Xiaoye, Tao, Xiubin
• Format: Article
• Language: English
• Subjects: Critical Illness - nursing; Decision Making; Evaluation Studies as Topic; Evidence-Based Practice - methods; Female; Health Planning Guidelines; Humans; Intensive Care Units - statistics & numerical data; Male; Meta-Analysis as Topic; Muscle Weakness - epidemiology; Muscle Weakness - etiology; Muscle Weakness - prevention & control; Prevalence; Risk Factors; Study Protocol Systematic Review; Systematic Review as Topic
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000021926

Intensive care unit-acquired weakness (ICU-AW) is an acquired neuromuscular lesion and a common occurrence in patients who are critically ill. There are already systematic reviews on ICU-AW. Therefore, we provide a protocol for an overview of systematic reviews to improve the effectiveness of the construction of an evidence-based practice for prevention of ICU-AW. We will search the PubMed, CINAHL, EMBASE, and the Cochrane Library for the relevant systematic review or meta-analyses about ICU-AW. Study selection, data extraction, and the quality assessment of the included studies will be performed independently by 2 reviewers. And the methodological quality, report quality and evidence quality will be evaluated by Assessment of Multiple Systematic Reviews-2 tool, Preferred Reporting Items for Systematic Reviews and Meta Analyses Statement checklist and Grading of Recommendations Assessment, Development and Evaluation system, respectively. This overview of systematic reviews and meta-analysis will collect the evidence published about the ICU-AW. We hope that our research will contribute to clinicians and public decision making about the ICU-AW. INPLASY202070067.