In Vitro Activities of Ravuconazole and Isavuconazole against Dematiaceous Fungi

The activities of 11 antifungals against 84 dematiaceous fungi were tested. For most tested fungal species, the MIC values of ravuconazole and isavuconazole were lower than those obtained with itraconazole, voriconazole, and posaconazole. Ravuconazole and isavuconazole appear to be more efficient ag...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2020-08, Vol.64 (9)
Main Authors: Zheng, Hailin, Song, Nana, Mei, Huan, Dong, Jiacheng, Li, Dongmei, Li, Xiaofang, Liu, Weida
Format: Article
Language:English
Subjects:
Susceptibility
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Summary:The activities of 11 antifungals against 84 dematiaceous fungi were tested. For most tested fungal species, the MIC values of ravuconazole and isavuconazole were lower than those obtained with itraconazole, voriconazole, and posaconazole. Ravuconazole and isavuconazole appear to be more efficient against most dematiaceous fungal infections than the other triazoles. However, some pigmented fungi, such as and , remain more susceptible to other triazoles or to echinocandins.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00643-20