Genomic Analysis Reveals Antibiotic-Susceptible Clones and Emerging Resistance in Neisseria gonorrhoeae in Saskatchewan, Canada

Whole-genome sequencing was used to identify mutations in antibiotic resistance-conferring genes to compare susceptibility predictions with MICs and to ascertain strain types in 99 isolates of Genotypes associated with susceptibility, as well as MIC creep or emerging resistance, were noted. Phylogen...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2020-08, Vol.64 (9)
Main Authors: Parmar, Nidhi R, Singh, Reema, Martin, Irene, Perera, Sumudu R, Demczuk, Walter, Kusalik, Anthony, Minion, Jessica, Dillon, Jo-Anne R
Format: Article
Language:English
Subjects:
Epidemiology and Surveillance
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Summary:Whole-genome sequencing was used to identify mutations in antibiotic resistance-conferring genes to compare susceptibility predictions with MICs and to ascertain strain types in 99 isolates of Genotypes associated with susceptibility, as well as MIC creep or emerging resistance, were noted. Phylogenomic analysis revealed three distinctive clades and putative gonococcal transmission linkages involving a tetracycline-resistant outbreak and the clonal spread of susceptible isolates in men.
ISSN:0066-4804
1098-6596
DOI:10.1128/aac.02514-19