Automated pneumatic shuttle for magnetic field cycling and parahydrogen hyperpolarized multidimensional NMR

[Display omitted] •Robust pneumatic shuttling for magnetic field cycling.•Accurate relaxation and lifetime measurements at variable fields.•Automated SABRE hyperpolarization enables multi-scan measurements.•Hyperpolarized multidimensional spectra facilitate study of chemical dynamics. We present a s...

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Bibliographic Details
Published in:Journal of magnetic resonance (1997) 2020-03, Vol.312, p.106700-106700, Article 106700
Main Authors: TomHon, Patrick, Akeroyd, Evan, Lehmkuhl, Sören, Chekmenev, Eduard Y., Theis, Thomas
Format: Article
Language:English
Subjects:
Hyperpolarization
Magnetic field cycling
Parahydrogen
Pneumatic shuttling
SABRE
Singlet states
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Summary:[Display omitted] •Robust pneumatic shuttling for magnetic field cycling.•Accurate relaxation and lifetime measurements at variable fields.•Automated SABRE hyperpolarization enables multi-scan measurements.•Hyperpolarized multidimensional spectra facilitate study of chemical dynamics. We present a simple-to-implement pneumatic sample shuttle for automation of magnetic field cycling and multidimensional NMR. The shuttle system is robust allowing automation of hyperpolarized and non-hyperpolarized measurements, including variable field lifetime measurements, SABRE polarization optimization, and SABRE multidimensional experiments. Relaxation-protected singlet states are evaluated by variable-field T1 and TS measurements. Automated shuttling facilitates characterization of hyperpolarization dynamics, field dependence and polarization buildup rates. Furthermore, reproducible hyperpolarization levels at every shuttling event enables automated 2D hyperpolarized NMR, including the first inverse 15N/1H HSQC. We uncover binding mechanisms of the catalytic species through cross peaks that are not accessible in standard one-dimensional hyperpolarized experiments. The simple design of the shuttling setup interfaced with standard TTL signals allows easy adaptation to any standard NMR magnet.
ISSN:1090-7807
1096-0856
DOI:10.1016/j.jmr.2020.106700