Cerebrospinal fluid features in SARS-CoV-2 RT-PCR positive patients

This study analyzed the cerebrospinal fluid features of 31 COVID-19 patients with neurological complications. We observed neither SARS-CoV-2 RNA in the cerebrospinal fluid, nor intrathecal IgG synthesis, but did observe signs of blood-brain barrier disruption. These results might serve as a basis fo...

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Bibliographic Details
Published in:Clinical infectious diseases 2020-08
Main Authors: Bellon, Mathilde, Schweblin, Cecilia, Lambeng, Nathalie, Cherpillod, Pascal, Vazquez, Jessica, Lalive, Patrice H, Schibler, Manuel, Deffert, Christine
Format: Article
Language:English
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Brief Report
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Summary:This study analyzed the cerebrospinal fluid features of 31 COVID-19 patients with neurological complications. We observed neither SARS-CoV-2 RNA in the cerebrospinal fluid, nor intrathecal IgG synthesis, but did observe signs of blood-brain barrier disruption. These results might serve as a basis for a better understanding of SARS-CoV-2 related neuropathogenesis.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciaa1165