Diagnostic significance of C-reactive protein and hematological parameters in acute toxoplasmosis

Toxoplasmosis is a zoonosis caused by Toxoplasma gondii , which can be acquired by oral contact and may cause severe health problems especially for pregnant (congenital toxoplasmosis) and immunocompromised patients. This study aimed to verify the diagnostic significance of hematological parameters a...

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Bibliographic Details
Published in:Journal of parasitic diseases 2020-12, Vol.44 (4), p.785-793
Main Authors: Sandri, Vanessa, Gonçalves, Itamar Luís, Machado das Neves, Gustavo, Romani Paraboni, Marisa Lucia
Format: Article
Language:English
Subjects:
Antibodies
Bayesian analysis
C-reactive protein
Health Promotion and Disease Prevention
Hematology
Immunocompromised hosts
Immunoglobulin G
Immunoglobulin M
Infectious Diseases
Leukocytes (neutrophilic)
Lymphocytes
Medicine
Medicine & Public Health
Neutrophils
Original
Original Article
Proteins
Protozoa
Toxoplasma gondii
Toxoplasmosis
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Summary:Toxoplasmosis is a zoonosis caused by Toxoplasma gondii , which can be acquired by oral contact and may cause severe health problems especially for pregnant (congenital toxoplasmosis) and immunocompromised patients. This study aimed to verify the diagnostic significance of hematological parameters and C-reactive protein (CRP) for toxoplasmosis acute detection. A case-control study was carried out between December 2017 and May 2018, in samples of convenience independent of age and sex. The case group was formed by 25 patients with positive anti- Toxoplasma gondii IgG/IgM antibody and the control group was formed by 21 patients with non-positive anti- Toxoplasma gondii IgG/IgM antibody. The results of the hematological parameters and CRP were analyzed in these patients. The patients with Toxoplasma gondii IgM antibody reagent showed higher lymphocytes counting and lower neutrophils counting than the control group. C-reactive protein levels were not different between the groups case and control. ROC curve analysis highlighted that the  cut - off value of > 32.00% for lymphocytes and
ISSN:0971-7196
0975-0703
DOI:10.1007/s12639-020-01262-0