GCNT4 is Associated with Prognosis and Suppress Cell Proliferation in Gastric Cancer

GCNT4 is a member of the glucosaminyl (N-acetyl) transferases family that has been implicated in multiple human malignancies. However, the role of GCNT4 in gastric cancer (GC) is unknown. In this present study, we aimed to explore the role and clinicopathological correlation of GCNT4 in GC. We first...

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Bibliographic Details
Published in:OncoTargets and therapy 2020-01, Vol.13, p.8601-8613
Main Authors: Sun, Hui, Chang, Jinjia, Ye, Min, Weng, Weiwei, Zhang, Meng, Ni, Shujuan, Tan, Cong, Huang, Dan, Wang, Lei, Du, Xiang, Xu, Mi-Die, Sheng, Weiqi
Format: Article
Language:English
Subjects:
Antibodies
Biopsy
Cell cycle
Cell growth
Cell proliferation
Chemotherapy
Datasets
Endoscopy
Flow cytometry
Gastric cancer
Gene expression
Genomes
Immunohistochemistry
Medical prognosis
Metastases
Metastasis
Original Research
Proteins
Statistical analysis
Tumors
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Summary:GCNT4 is a member of the glucosaminyl (N-acetyl) transferases family that has been implicated in multiple human malignancies. However, the role of GCNT4 in gastric cancer (GC) is unknown. In this present study, we aimed to explore the role and clinicopathological correlation of GCNT4 in GC. We first evaluated the dysregulation of GCNT4 in The Cancer Genome Atlas (TCGA) and then we performed RT-qPCR and immunohistochemistry to validate the results in a cohort of in-house patients. The clinicopathological correlation and function of GCNT4 in GC were also analysed. GCNT4 was found to be significantly downregulated in GC. In addition, GCNT4 expression correlated with tumour depth, nervous invasion and pathological tumor-node-metastasis (pTNM) stage. Moreover, lower GCNT4 levels conferred poor overall survival (OS) and disease-free survival (DFS) to GC patients. Multivariate Cox regression analysis revealed that GCNT4 protein expression is an independent prognostic factor for OS in patients with GC. Further functional experimental results revealed that overexpression of GCNT4 appears to halt GC cell proliferation and the cell cycle. Altogether, these findings indicated that GCNT4 regulates the GC cell cycle and have important implications for the selection of therapeutic targets to prevent tumour proliferation.
ISSN:1178-6930
1178-6930
DOI:10.2147/OTT.S248997