Current status of Helicobacter pylori eradication and risk factors for eradication failure

• Published in: World journal of gastroenterology : WJG 2020-08, Vol.26 (32), p.4846-4856
• Main Authors: Yan, Tian-Lian, Gao, Jian-Guo, Wang, Jing-Hua, Chen, Dan, Lu, Chao, Xu, Cheng-Fu
• Format: Article
• Language: English
• Subjects: Aged; Amoxicillin - therapeutic use; Anti-Bacterial Agents - adverse effects; China - epidemiology; Clarithromycin - therapeutic use; Drug Therapy, Combination; Helicobacter Infections - diagnosis; Helicobacter Infections - drug therapy; Helicobacter Infections - epidemiology; Helicobacter pylori; Humans; Proton Pump Inhibitors - therapeutic use; Retrospective Study; Risk Factors
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/WJG.V26.I32.4846

The ( ) eradication rate is decreasing in the general population of China. To evaluate the eradication status in real-world clinical practice and to explore factors related to eradication failure. Patients with infection who were treated with standard 14-d quadruple therapy and received a test of cure at a provincial medical institution between June 2018 and May 2019 were enrolled. Demographic and clinical data were recorded. Eradication rates were calculated and compared between regimens and subgroups. Multivariate analysis was performed to identify predictors of eradication failure. Of 2610 patients enrolled, eradication was successful in 1999 (76.6%) patients. Amoxicillin-containing quadruple regimens showed a higher eradication rate than other quadruple therapy regimens (83.0% 69.0%, < 0.001). The quadruple therapy containing amoxicillin plus clarithromycin achieved the highest eradication rate (83.5%). Primary therapy had a higher eradication rate than rescue therapy (78.3% 66.5%, < 0.001). In rescue therapy, the amoxicillin- and furazolidone-containing regimens achieved the highest eradication rate (80.8%). Esomeprazole-containing regimens showed a higher eradication rate than those containing other proton pump inhibitors (81.8% 74.9%, = 0.001). Multivariate regression analysis found that older age, prior therapy, and use of omeprazole or pantoprazole were associated with an increased risk of eradication failure. The total eradication rate is 76.6%. Amoxicillin-containing regimens are superior to other regimens. Age, prior therapy, and use of omeprazole or pantoprazole are independent risk factors for eradication failure.