Association between Body Mass Index and Reproductive Outcome in Women with Polycystic Ovary Syndrome Receiving IVF/ICSI-ET

• Published in: BioMed research international 2020, Vol.2020 (2020), p.1-7
• Main Authors: Wang, Wei, Cui, Na, Yang, Aimin, Luo, Zhuoye, Zhang, Dan, Zhou, Han, Hao, Guimin
• Format: Article
• Language: English
• Subjects: Abortion, Spontaneous - metabolism; Abortion, Spontaneous - physiopathology; Adult; Age; Autoimmune diseases; Biomedical research; Birth Rate; Body mass; Body Mass Index; Body size; Body weight; Diabetes; Embryo Implantation - physiology; Embryo transfer; Embryo Transfer - methods; Embryos; Female; Fertilization in Vitro - methods; Gametocytes; Gonadotropins; Gonadotropins - metabolism; Humans; Identification methods; Implantation; In vitro fertilization; Infertility; Miscarriage; Normal distribution; Obesity; Obesity - metabolism; Obesity - physiopathology; Oocytes; Oocytes - metabolism; Oocytes - physiology; Ovaries; Overweight; Overweight - metabolism; Overweight - physiopathology; Ovulation Induction - methods; Pituitary (anterior); Polycystic ovary syndrome; Polycystic Ovary Syndrome - metabolism; Polycystic Ovary Syndrome - physiopathology; Pregnancy; Pregnancy Rate; Premature birth; Regression analysis; Reproduction - physiology; Reproductive technologies; Retrospective Studies; Sperm Injections, Intracytoplasmic - methods; Standard deviation; Statistical analysis; Testosterone; Thinness - metabolism; Thinness - physiopathology; Thyroid diseases; Ultrasonic imaging; Underweight; Variance analysis; Weight reduction; Womens health
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2020/6434080

Objective. To examine the association between body mass index (BMI) and the outcome of in vitro fertilization or intracytoplasmic sperm injection embryo transfer- (IVF/ICSI-ET) assisted reproduction in women with polycystic ovary syndrome (PCOS) receiving the ultra-long agonist protocol. Methods. We retrospectively identified all women receiving IVF/ICSI-ET for the first time using the ultra-long protocol between January 2013 and January 2018 at our hospital. Only women at ≤35 years of age receiving the first cycle were analyzed. Results. A total of 1782 women were included in the analysis: 42 were underweight, 742 were overweight, 198 were obese, and 800 were normal weight. Gonadotropin dosage and duration were comparable between underweight and normal weight groups but were significantly higher/longer in overweight and obese groups (P