The Role of Pro-Resolving Lipid Mediators in Colorectal Cancer-Associated Inflammation: Implications for Therapeutic Strategies

Inflammation is a recognized hallmark of cancer that contributes to the development and progression of colorectal cancer (CRC). Anti-inflammatory drugs currently used for the treatment of CRC show many adverse side effects that prompted researchers to propose the polyunsaturated fatty acids-derived...

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Bibliographic Details
Published in:Cancers 2020-08, Vol.12 (8), p.2060
Main Authors: Ungaro, Federica, D’Alessio, Silvia, Danese, Silvio
Format: Article
Language:English
Subjects:
Anti-inflammatory agents
Cancer
Cancer therapies
Colorectal cancer
Colorectal carcinoma
Complications and side effects
Drug development
Fatty acids
Health aspects
Hormone replacement therapy
Inflammation
Inflammatory bowel disease
Lipids
Liver
Metastasis
Mortality
Mutation
Nonsteroidal anti-inflammatory drugs
Polyunsaturated fatty acids
Review
Smoking cessation
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Summary:Inflammation is a recognized hallmark of cancer that contributes to the development and progression of colorectal cancer (CRC). Anti-inflammatory drugs currently used for the treatment of CRC show many adverse side effects that prompted researchers to propose the polyunsaturated fatty acids-derived specialized pro-resolving mediators (SPMs) as promoters of resolution of cancer-associated inflammation. SPMs were found to inhibit the CRC-associated pro-inflammatory milieu via specific G-coupled protein receptors, although clinical data are still lacking. This review aims to summarize the state-of-the-art in this field, ultimately providing insights for the development of innovative anti-CRC therapies that promote the endogenous lipid-mediated resolution of CRC-associated inflammation.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers12082060