MiR-155-5p and MiR-203a-3p Are Prognostic Factors in Soft Tissue Sarcoma

Soft tissue sarcoma (STS) is a heterogeneous group of rare malignancies with a five-year survival rate of approximately 50%. Reliable molecular markers for risk stratification and subsequent therapy management are still needed. Therefore, we analyzed the prognostic potential of miR-155-5p and miR-20...

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Bibliographic Details
Published in:Cancers 2020-08, Vol.12 (8), p.2254
Main Authors: Greither, Thomas, Koser, Franziska, Holzhausen, Hans-Jürgen, Güttler, Antje, Würl, Peter, Kappler, Matthias, Wach, Sven, Taubert, Helge
Format: Article
Language:English
Subjects:
Bone cancer
Cell growth
Gene expression
Genetic aspects
Health aspects
Hypoxia
Kinases
Leukemia
Liposarcoma
Lymphoma
Medical prognosis
MicroRNA
MicroRNAs
miRNA
mRNA
Patients
Regression analysis
Risk assessment
Sarcoma
Soft tissue sarcoma
Survival
Tumor suppressor genes
Tumors
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Summary:Soft tissue sarcoma (STS) is a heterogeneous group of rare malignancies with a five-year survival rate of approximately 50%. Reliable molecular markers for risk stratification and subsequent therapy management are still needed. Therefore, we analyzed the prognostic potential of miR-155-5p and miR-203a-3p expression in a cohort of 79 STS patients. MiR-155-5p and miR-203a-3p expression was measured from tumor total RNA by qPCR and correlated with the demographic, clinicopathological, and prognostic data of the patients. Elevated miR-155-5p expression was significantly associated with increased tumor stage and hypoxia-associated mRNA/protein expression. High miR-155-5p expression and low miR-203a-3p expression, as well as a combination of high miR-155-5p and low miR-203a-3p expression, were significantly associated with poor disease-specific survival in STS patients in the Kaplan–Meier survival analyses (p = 0.027, p = 0.001 and p = 0.0003, respectively) and in the univariate Cox regression analyses (RR = 1.96; p = 0.031; RR = 2.59; p = 0.002 and RR = 4.76; p = 0.001, respectively), but not in the multivariate Cox regression analyses. In conclusion, the oncomiR miR-155-5p and the tumor suppressor-miR miR-203a-3p exhibit an association with STS patient prognosis and are suggested as candidates for risk assessment.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers12082254