The Role of Necroptosis in ROS-Mediated Cancer Therapies and Its Promising Applications

Over the past decades, promising therapies targeting different signaling pathways have emerged. Among these pathways, apoptosis has been well investigated and targeted to design diverse chemotherapies. However, some patients are chemoresistant to these therapies due to compromised apoptotic cell dea...

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Bibliographic Details
Published in:Cancers 2020-08, Vol.12 (8), p.2185
Main Authors: Hsu, Sheng-Kai, Chang, Wen-Tsan, Lin, I-Ling, Chen, Yih-Fung, Padalwar, Nitin Balkrushna, Cheng, Kai-Chun, Teng, Yen-Ni, Wang, Chi-Huei, Chiu, Chien-Chih
Format: Article
Language:English
Subjects:
Apoptosis
Breast cancer
Cancer
Cancer therapies
Care and treatment
Caspase
Cell death
Cell growth
Chemotherapy
Drug resistance
Drugs
Enzymes
Kinases
Leukemia
Ligands
Molecular modelling
Mutation
Necroptosis
Phosphorylation
Physiology
Proteins
Reactive oxygen species
Review
Tumor necrosis factor-TNF
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Summary:Over the past decades, promising therapies targeting different signaling pathways have emerged. Among these pathways, apoptosis has been well investigated and targeted to design diverse chemotherapies. However, some patients are chemoresistant to these therapies due to compromised apoptotic cell death. Hence, exploring alternative treatments aimed at different mechanisms of cell death seems to be a potential strategy for bypassing impaired apoptotic cell death. Emerging evidence has shown that necroptosis, a caspase-independent form of cell death with features between apoptosis and necrosis, can overcome the predicament of drug resistance. Furthermore, previous studies have also indicated that there is a close correlation between necroptosis and reactive oxygen species (ROS); both necroptosis and ROS play significant roles both under human physiological conditions such as the regulation of inflammation and in cancer biology. Several small molecules used in experiments and clinical practice eliminate cancer cells via the modulation of ROS and necroptosis. The molecular mechanisms of these promising therapies are discussed in detail in this review.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers12082185