Neoadjuvant Radiotherapy-Related Wound Morbidity in Soft Tissue Sarcoma: Perspectives for Radioprotective Agents

Historically, patients with localized soft tissue sarcomas (STS) of the extremities would undergo limb amputation. It was subsequently determined that the addition of radiation therapy (RT) delivered prior to (neoadjuvant) or after (adjuvant) a limb-sparing surgical resection yielded equivalent surv...

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Bibliographic Details
Published in:Cancers 2020-08, Vol.12 (8), p.2258
Main Authors: Callaghan, Cameron M, Hasibuzzaman, M M, Rodman, Samuel N, Goetz, Jessica E, Mapuskar, Kranti A, Petronek, Michael S, Steinbach, Emily J, Miller, Benjamin J, Pulliam, Casey F, Coleman, Mitchell C, Monga, Varun V, Milhem, Mohammed M, Spitz, Douglas R, Allen, Bryan G
Format: Article
Language:English
Subjects:
Amputation
Dermatitis
Drug therapy
Edema
Fractures
Morbidity
Neoadjuvant therapy
Patient outcomes
Radiation therapy
Radioisotopes
Radioprotective agents
Review
Sarcoma
Soft tissue sarcoma
Studies
Surgery
Toxicity
Tumors
Wound healing
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Summary:Historically, patients with localized soft tissue sarcomas (STS) of the extremities would undergo limb amputation. It was subsequently determined that the addition of radiation therapy (RT) delivered prior to (neoadjuvant) or after (adjuvant) a limb-sparing surgical resection yielded equivalent survival outcomes to amputation in appropriate patients. Generally, neoadjuvant radiation offers decreased volume and dose of high-intensity radiation to normal tissue and increased chance of achieving negative surgical margins-but also increases wound healing complications when compared to adjuvant radiotherapy. This review elaborates on the current neoadjuvant/adjuvant RT approaches, wound healing complications in STS, and the potential application of novel radioprotective agents to minimize radiation-induced normal tissue toxicity.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers12082258