Angiotensin-converting enzyme gene D-allele and the severity of coronary artery disease

Coronary artery disease (CAD) is the first cause of morbidity and mortality worldwide. An important goal is to diagnose patients in early stages, in order to reduce acute cardiovascular events. The angiotensin-converting enzyme (ACE) is an important element for the cardiovascular system, through its...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2020-10, Vol.20 (4), p.3407-3411
Main Authors: Vladeanu, Maria-Cristina, Bojan, Iris Bararu, Bojan, Andrei, Iliescu, Dan, Badescu, Minerva Codruta, Badulescu, Oana Viola, Badescu, Magda, Georgescu, Catalina Arsenescu, Ciocoiu, Manuela
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Age
Angiotensin converting enzyme inhibitors
Angiotensins
Blood pressure
Cardiovascular agents
Cardiovascular disease
Cholesterol
Coronary heart disease
Coronary vessels
Deoxyribonucleic acid
DNA
Enzymes
Family medical history
Genes
Genetic aspects
Genetic engineering
Genetic polymorphisms
Genetic research
Genotype & phenotype
Health aspects
Heart attacks
Hemoglobin
Males
Medical imaging
Medical research
Mortality
Mutation
Polymorphism
Risk factors
Romania
Triglycerides
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Summary:Coronary artery disease (CAD) is the first cause of morbidity and mortality worldwide. An important goal is to diagnose patients in early stages, in order to reduce acute cardiovascular events. The angiotensin-converting enzyme (ACE) is an important element for the cardiovascular system, through its actions on hydro-salin balance and vascular tone. ACE polymorphism consists of insertions (I)/deletions (D) and there are 3 genotypes: II, ID, DD. It is speculated that the DD genotype may be a genetic basis for severe CAD, while the II genotype may have a protective effect on the coronary arteries. The present study included 154 patients with acute coronary syndroms admitted to the Institute for Cardiovascular Disease 'George I.M. Georgescu', Iasi. The patients underwent coronary angiography in order to assess the severity of the lesions and the ACE genotypes were determined for each patient. The genotypes were correlated with the severity of the vessel-disease and the exposure to classic risk factors. It was concluded that the D-allele is associated with a greater risk for acute coronary events and severe coronary stenosis, especially when risk genotype and risk phenotype interact. Key words: angiotensin-converting enzyme gene, gene polymorphism, D-allele, I-allele, coronary artery disease, unstable angina, acute myocardial infarction
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2020.8978