The Prowess of Andrographolide as a Natural Weapon in the War against Cancer

There has been a paradigm shift in our understanding about the multifaceted nature of cancer, and a wealth of information has revealed that single-target drugs are not good enough to provide satisfactory clinical outcomes and therapeutic effects for complex diseases which involve multiple factors. T...

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Bibliographic Details
Published in:Cancers 2020-08, Vol.12 (8), p.2159
Main Authors: Farooqi, Ammad Ahmad, Attar, Rukset, Sabitaliyevich, Uteuliyev Yerzhan, Alaaeddine, Nada, de Sousa, Damião Pergentino, Xu, Baojun, C. Cho, William
Format: Article
Language:English
Subjects:
Apoptosis
Cancer
Cell proliferation
Clinical trials
Diterpenes
Drug dosages
Health aspects
Inflammatory bowel disease
Intracellular signalling
Kinases
Leukemia
Metabolism
Metabolites
Metastasis
Natural products
Pharmacokinetics
Phosphorylation
Proteins
Review
Signal transduction
Terpenoids
TOR protein
Vascular endothelial growth factor
Wnt protein
β-Catenin
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Summary:There has been a paradigm shift in our understanding about the multifaceted nature of cancer, and a wealth of information has revealed that single-target drugs are not good enough to provide satisfactory clinical outcomes and therapeutic effects for complex diseases which involve multiple factors. Therefore, there has been a reignition to search for natural products having premium pharmacological activities aim to efficiently target multiple deregulated cellular signaling pathways. Andrographolide, a diterpene lactone from Andrographis paniculata was brought into to the limelight because of its ability to inhibit cancer cell proliferation and induce apoptosis. Here we reviewed andrographolide on cellular pathways regulation including Wnt/β-catenin, mTOR, VEGF-mediated intracellular signaling, as well as TRAIL-mediated apoptosis to inhibit cancer development.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers12082159